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MetabolomicsF1Fo-ATP synthase subunit determines lethal pathogenic fungi infection
Fungal infections, especially candidiasis and aspergillosis, claim an unacceptably high fatality rate. The energy ATP that is necessary for fungal cell growth and function is synthesized mainly through oxidative phosphorylation, with the key enzyme being F1Fo-ATP synthase. But it remains unknown how...
2021-10-08 | MTBLS3332 | MetaboLights
ProteomicsSmall and large ribosomal subunit deficiencies lead to distinct gene expression signatures that reflect cellular growth rate
Levels of the ribosome, the conserved molecular machine that mediates translation, are tightly linked to cellular growth rate. In humans, ribosomopathies are diseases associated with cell-type-specific pathologies and reduced ribosomal protein (RP) levels. Because gene expression defects resulting f...
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2018-10-12 | MSV000083033 | MassIVE
GenomicsDeconvolution ChIP-seq profiling of UBF and RPA194 in K562 cells to identify analogous enhancer structures on mouse and human ribosomal RNA genes
The combination of Chromatin Immunoprecipitation and Massively Parallel Sequencing, or ChIP-Seq, has greatly advanced our genome-wide understanding of chromatin and enhancer structures. However, its resolution at any given genetic locus is limited by several factors. In applying ChIP-Seq to study th...
ORGANISM(S): Homo sapiens 
2017-12-31 | E-MTAB-6032 | biostudies-arrayexpress
TranscriptomicsRibosomal Protein Gene Deletions in Diamond Blackfan Anemia
Diamond Blackfan anemia is a congenital bone marrow failure syndrome characterized by hypoproliferative anemia, often with associated physical abnormalities. Perturbations of the ribosome appear critically important to the development of DBA, as alterations in 9 different ribosomal protein genes ha...
ORGANISM(S): Homo sapiens 
2012-01-15 | E-GEOD-31575 | biostudies-arrayexpress
TranscriptomicsEffects of Mediator subunit gene-deletions under conditions that repress ribosome synthesis
Transcriptional repression of ribosomal components and tRNAs is coordinately regulated in response to a wide variety of environmental stresses. Part of this response involves the convergence of different nutritional and stress signaling pathways on Maf1, a protein that is essential for repressing tr...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-01 | E-GEOD-11397 | biostudies-arrayexpress
ProteomicsUFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER
Supporting MS data for paper (doi: 10.1038/s41586-024-07073-0) by DaRosa P.A., Penchev I. et al., titled "UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER". Index of MS supporting files uploaded: Related to Related to Fig. 1b, c (xb01004(UFM1), xb01005(SBP-UFM1): LFQ IP-MS (Un...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-12-22 | MSV000093721 | MassIVE
ProteomicsUFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER
Supporting MS data for paper (doi: 10.1038/s41586-024-07073-0) by DaRosa P.A., Penchev I. et al., titled "UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER". Index of MS supporting files uploaded: - Related to Fig. 1a and Extended Data Fig. 1a (AO3435-AO3440: TMT proteomics (Un...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-11-27 | MSV000093510 | MassIVE
Transcriptomicsrpl24b/WT polysome loading and transcript levels (Arabidopsis thaliana)
To understand the contribution of the RPL24B protein, a component of the large 60S ribosomal subunit, to the translation of specific mRNAs, we compared the ribosome occupancy of mRNAs in wild type Arabidopsis and the rpl24b/stv1-1 T-DNA insertion mutant. RNA was fractionated using sucrose gradients ...
ORGANISM(S): Arabidopsis thaliana 
2014-01-01 | E-GEOD-51474 | biostudies-arrayexpress
GenomicsThe roles of GTPases in biogenesis of the large ribosomal subunit
The roles of GTPases in biogenesis of the large ribosomal subunit
PRJNA1289073 | ENA
GenomicsStructural basis of ribosomal 30S subunit degradation by RNase R
Structural basis of ribosomal 30S subunit degradation by RNase R
PRJNA1055080 | ENA
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