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TranscriptomicsFunctionally diverse dendritic mRNAs rapidly associate with ribosomes following a novel experience
The subcellular localization and translation of messenger RNA (mRNA) supports functional differentiation between cellular compartments. In neuronal dendrites, local translation of mRNA provides a rapid and specific mechanism for synaptic plasticity and memory formation, and might be involved in the ...
ORGANISM(S): Mus musculus 
2014-07-30 | E-GEOD-58343 | biostudies-arrayexpress
ProteomicsDirect Interactions of RNA Polymerase with Ribosomes and Ribosomal Subunits in E. Coli
The interactions between RNA polymerase and ribosomes are critical for the coordination of transcription with translation. We report that RNA polymerase directly binds ribosomes and isolated large and small ribosomal subunits.
ORGANISM(S): Escherichia coli 
2017-08-28 | PXD006717 | Pride
Ribosomes Mass spectrometry E. coli Rna polymerase 
GenomicsFMRP Regulates Neuronal RNA Granules Containing Stalled Ribosomes, Not Where Ribosomes Stall
FMRP Regulates Neuronal RNA Granules Containing Stalled Ribosomes, Not Where Ribosomes Stall
PRJNA1234679 | ENA
TranscriptomicsTranscript residency on ribosomes reveals a key role for the Arabidopsis thaliana bundle sheath in sulphur and glucosinolate metabolism.
Leaves of angiosperms are made up of multiple distinct cell types. While the function of mesophyll cells, guard cells, phloem companion cells and sieve elements are clearly described, this is not the case for the bundle sheath (BS). To provide insight into the role of the BS in the C3 species Arabi...
ORGANISM(S): Arabidopsis thaliana 
2014-02-02 | E-MTAB-4474 | biostudies-arrayexpress
GenomicsComparative Ribo-Seq of Staphylococcus aureus harboring A2058-unmodified ribosomes and m6A2058-modified ribosomes
Comparative Ribo-Seq of Staphylococcus aureus harboring A2058-unmodified ribosomes and m6A2058-modified ribosomes
PRJNA706704 | ENA
TranscriptomicsThe ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragments
Recent studies highlight the importance of translational control in determining protein abundance, underscoring the value of measuring gene expression at the level of translation. We present a protocol for genome-wide, quantitative analysis of in vivo translation by deep sequencing. This ribosome pr...
ORGANISM(S): Homo sapiens 
2012-07-26 | E-GEOD-37744 | biostudies-arrayexpress
ProteomicscGAS Senses Translation Stress Through Direct Binding to Ribosomes
The cGAS-STING pathway, a central component of the innate immune system, senses cytosolic DNA and induces interferon-stimulated genes (ISGs) to mediate inflammation. Here we report the unexpected discovery that cGAS senses dysfunctional protein production. Purified ribosomes interact with and stimul...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD019359 | Pride
Ribosomes Ascc Human Cgas 
ProteomicsQuantitative mass spectrometry analysis of 70S ribosomes from iSAT
The ribosome is one of the largest and the most complicated enzymes in cells, making up 25% of the bacterial cell’s dry mass, and is responsible for protein synthesis in all organisms on earth. In 2013, Jewett et al. reported an in vitro system named integrated rRNA synthesis, ribosome assembly, and...
ORGANISM(S): Escherichia coli 
2023-05-10 | PXD038716 | Pride
In vitro 70s Ribosome Lc-ms/ms 
TranscriptomicsAffinity purification of ribosomes and associated RNAs from stress-treated cells using tagged Rpl16a and Rpl16b
This SuperSeries is composed of the following subset Series: GSE13653: Affinity purification of ribosomes and associated RNAs from stress-treated cells GSE13654: Affinity purification of ribosomes and associated RNAs using tagged Rpl16a and Rpl16b Refer to individual Series
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-25 | E-GEOD-13682 | biostudies-arrayexpress
ProteomicsA molecular network of conserved factors keeps ribosomes dormant in the egg
Ribosomes are produced in large quantities during oogenesis and stored in the egg. However, the egg and early embryo are translationally inactive. How translation is activated during embryogenesis is poorly understood. Using mass-spectrometry and cryo-EM analyses of ribosomes isolated from zebrafish...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) Xenopus laevis (African clawed frog) 
2022-11-03 | PXD026866 | Pride
Cryo-em Cross-linking Xenopus Mass-spectrometry Ribosome Zebrafish 
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