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TranscriptomicsRNA-Seq of human K-562 leukaemia cell line with and without K700E mutation in coding region of SF3B1 gene
The aim of this experiment was to compare the transcriptomes of SF3B1 mutant and wildtype isogenic cells at the whole cell, nuclear and cytoplasmic levels. Mutations in SF3B1 are often found in the malignant cells of patients suffering from myelodysplastic syndromes and more rarely in other cancer t...
ORGANISM(S): Homo sapiens 
2019-02-25 | E-MTAB-7192 | biostudies-arrayexpress
TranscriptomicsExpression data from human glioma cancer stem cell (CSC) specimens following knockdown of GREM1
CSCs differentially secrete the BMP antagonist Gremlin1 compared to non-stem glioma populations. Knockdown of Gremlin1 decreases CSC proliferation and tumorigenicity, establishing Gremlin1 as an essential effector for CSC maintenance. We used a microarray to determine the gene expression programs t...
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-52846 | biostudies-arrayexpress
TranscriptomicsGlobal Analysis of Glucocorticoid Receptor-Associated Transcripts and Identification of a Target RNA Motif
Posttranscriptional regulation is emerging as a key factor in glucocorticoid (GC)-mediated gene regulation. We investigated the role of the human glucocorticoid receptor (GR) as an RNA-binding protein and its effect on mRNA turnover in human airway epithelial cells. Cell treatment with the potent ...
ORGANISM(S): Homo sapiens 
2011-06-24 | E-GEOD-24748 | biostudies-arrayexpress
UnknownDense fibrillar collagen is a potent inducer of invadopodia via a specific signaling network
Not available
S-JCBD-201405099 | bioimages
TranscriptomicsDetection and Characterization of Gene Expression Differences in Transgenic Glycine max Seeds with RNAseq
Transformation of Glycine max with seed-targeted expression vectors via Agrobacterium causes measurable unscripted gene expression changes in the seed transcriptome Overall design: mRNA was sequenced from three transgenic events expressing three different recombinant proteins in soybean seeds. Three...
ORGANISM(S): Glycine max 
2015-10-06 | E-MTAB-4317 | biostudies-arrayexpress
TranscriptomicsGene expression profiling after stimulation of THP-1 cells with a2NTD
Background: Identifying the immune components that are regulated by a2NTD, a peptide cleaved from the N-terminus of the a2 vacuolar ATPase. Methods: In this study, we used pathway-focused PCR arrays to determine the genes that are regulated in human monocytic cell line, THP-1 after a2NTD stimulati...
ORGANISM(S): Homo sapiens 
2010-11-20 | E-GEOD-25490 | biostudies-arrayexpress
UnknownA high density SLAF-SNP genetic map and QTL detection for fibre quality traits in Gossypium hirsutum.
Not available
S-EPMC6282304 | biostudies-literature
ProteomicsInsights into pulmonary phosphate homeostasis and osteoclastogenesis emerge from the study of pulmonary alveolar microlithiasis
Pulmonary alveolar microlithiasis is an autosomal recessive lung disease caused by a deficiency in the pulmonary epithelial Npt2b sodium-phosphate co-transporter that results in accumulation of phosphate and formation of hydroxyapatite microliths in the alveolar space. The single cell transcriptomic...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2023-02-16 | MSV000091302 | MassIVE
TranscriptomicsMicroRNAs are amplifiers of monocyte inflammatory networks and repressors of metabolism
MicroRNAs are amplifiers of monocyte inflammatory networks and repressors of metabolism Milk and blood isolated CD14+ monocyte cells taken from 5 infected Holstein friesians and 5 control Holstein friesians. Five animal infected with live S. uberis, cells extracted at 0, 12, 24, 36, and 48 hours pos...
ORGANISM(S): Bos taurus 
2014-07-03 | E-GEOD-51848 | biostudies-arrayexpress
TranscriptomicsComparison of nucleotide-resolution, genome-wide transcriptome maps of Escherichia coli K12 strain BW25113 and Streptomyces coelicolor A3(2) strain M145.
This data contained within this entry was produced as part of a study that included differential RNA-sequencing. S. coelicolor and E. coli reference strains were grown in batch culture with shaking. The E. coli sample was extracted during mid-exponential growth, while the S. coelicolor sample was ex...
ORGANISM(S): Escherichia coli K-12 
2013-04-20 | E-GEOD-46232 | biostudies-arrayexpress
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