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TranscriptomicsFoxo1/3 depletion in granulosa cells reveals novel mechanisms controlling follicle growth and death and endocrine regulation of pituitary FSH.
The Foxo transcription factors regulate multiple cellular functions. Foxo1 and Foxo3 are highly expressed in granulosa cells of ovarian follicles. Selective depletion of the Foxo1 and Foxo3 genes in granulosa cells revealed a novel ovarian-pituitary endocrine feedback loop characterized by: 1) undet...
ORGANISM(S): Mus musculus 
2013-02-16 | E-GEOD-35593 | biostudies-arrayexpress
GenomicsNational Eye Institute Glaucoma Human Genetics Collaboration (NEIGHBOR) Consortium Glaucoma Genome-Wide Association Study

This is a case-control study of primary open angle glaucoma (POAG). POAG is an intraocular pressure (IOP) related progressive optic neuropathy that ultimately leads to blindness. For this study we have formed a collaborative consortium contributing 2170 POAG cases and 2347 controls with a unified...

phs000238.v1.p1 | EGA
TranscriptomicsFOXO1/3 and PTEN Depletion in Granulosa Cells Promotes Ovarian Granulosa Cell Tumor Development
The Forkhead Box, FOXO1 and FOXO3, transcription factors regulate multiple functions in mammalian cells. Selective inactivation of the Foxo1 and Foxo3 genes in murine ovarian granulosa cells severely impairs follicular development and apoptosis causing infertility, and as shown herein, granulosa cel...
ORGANISM(S): Mus musculus 
2015-06-17 | E-GEOD-67662 | biostudies-arrayexpress
UnknownCOVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study.
Not available
S-EPMC8231091 | biostudies-literature
UnknownTranscriptional regulation of p21/CIP1 cell cycle inhibitor by PDEF controls cell proliferation and mammary tumor progression.
Not available
S-EPMC2857004 | biostudies-literature
UnknownTax1bp1 enhances bacterial virulence and promotes inflammatory responses during <i>Mycobacterium tuberculosis</i> infection of alveolar macrophages.
Not available
S-EPMC11702572 | biostudies-literature
GenomicsUsf1, a Suppressor of the Circadian Clock Mutant, Reveals the Nature of the DNA-binding of the CLOCK:BMAL1 complex in mice
Genetic and molecular approaches have been critical for elucidating the mechanism of the mammalian circadian clock. Here, we demonstrate that the ClockM-NM-^T19 mutant behavioral phenotype is significantly modified by mouse strain genetic background. We map a suppressor of the ClockM-NM-^T19 mutatio...
ORGANISM(S): Mus musculus 
2013-04-21 | E-GEOD-44609 | biostudies-arrayexpress
UnknownThe nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors.
Not available
S-EPMC5018401 | biostudies-literature
UnknownProlonged Survival in Stage III Melanoma with Ipilimumab Adjuvant Therapy.
Not available
S-EPMC5648545 | biostudies-literature
UnknownInteractions of abiraterone, eplerenone, and prednisolone with wild-type and mutant androgen receptor: a rationale for increasing abiraterone exposure or combining with MDV3100.
Not available
S-EPMC4281708 | biostudies-literature
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