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GenomicsSpi-1/PU.1 activates transcription through clustered DNA occupancy in erythroleukemia
Acute leukemia are characterized by deregulation of transcriptional networks that control the lineage specificity of gene expression. The aberrant overexpression of the Spi-1/PU.1 transcription factor leads to erythroleukemia. To determine how Spi-1 mechanistically influences the transcriptional pro...
ORGANISM(S): Mus musculus 
2012-06-30 | E-GEOD-33611 | biostudies-arrayexpress
UnknownAssessing shared decision-making: a case study of third-year medical student standardized patient encounters.
Not available
S-EPMC12700522 | biostudies-literature
UnknownTargeting PLK1 Reduces MMP10 to Enhance Radiosensitivity in HPV- Head and Neck Cancer.
Not available
S-EPMC12752811 | biostudies-literature
UnknownPolo-like kinase 1 (Plk1) inhibition synergizes with taxanes in triple negative breast cancer.
Not available
S-EPMC6872222 | biostudies-literature
UnknownPLK1 Inhibitor Onvansertib Enhances the Efficacy of Alpelisib in PIK3CA-Mutated HR-Positive Breast Cancer Resistant to Palbociclib and Endocrine Therapy: Preclinical Insights.
Not available
S-EPMC11476299 | biostudies-literature
UnknownMoney Affects Theory of Mind Differently by Gender.
Not available
S-EPMC4669079 | biostudies-literature
UnknownOnvansertib treatment overcomes olaparib resistance in high-grade ovarian carcinomas.
Not available
S-EPMC11263393 | biostudies-literature
UnknownA novel PLK1 inhibitor onvansertib effectively sensitizes MYC-driven medulloblastoma to radiotherapy.
Not available
S-EPMC8917408 | biostudies-literature
UnknownReprogramming pancreatic stellate cells via p53 activation: A putative target for pancreatic cancer therapy.
Not available
S-EPMC5718507 | biostudies-literature
ProteomicsKinome profiling of shControl and shFANCA HL60 cells treated with volasertib
The Fanconi anemia (FA) pathway is a network of proteins critical to the preservation of genomic integrity and the prevention of cancer. FA proteins safeguard the genome by regulating the cell cycle and facilitating error-free repair of DNA damage. Bi-allelic mutation of genes encoding FA pathway pr...
ORGANISM(S): Homo sapiens (Human) 
2024-11-21 | PXD048014 | Pride
Polo-like kinase 1 Kinase inhibitor Acute myeloid leukemia Fanconi anemia 
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