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TranscriptomicsMicroRNA-203 represses selection and expansion of oncogenic HRas transformed tumor initiating cells [seq]
In many mouse models of skin cancer, only a few tumors typically form although many cells competent for tumorigenesis receive the same oncogenic mutations. These observations suggest a selection process for defining tumor initiating cells. Here we use quantitative mRNA- and miR-Seq to determine the ...
ORGANISM(S): Mus musculus 
2015-07-23 | E-GEOD-66054 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of Musashi-2 targets reveals novel functions in governing epithelial cell migration
The Musashi-2 (Msi2) RNA-binding protein maintains stem cell self-renewal and promotes oncogenesis by enhancing cell proliferation in hematopoietic and gastrointestinal tissues. However, it is unclear how Msi2 recognizes and regulates mRNA targets in vivo and whether Msi2 primarily controls cell gro...
ORGANISM(S): Mus musculus 
2016-04-01 | E-GEOD-71333 | biostudies-arrayexpress
TranscriptomicsMicroRNA-203 represses selection and expansion of oncogenic HRas transformed tumor initiating cells [array]
In many mouse models of skin cancer, only a few tumors typically form although many cells competent for tumorigenesis receive the same oncogenic mutations. These observations suggest a selection process for defining tumor initiating cells. Here we use quantitative mRNA- and miR-Seq to determine the ...
ORGANISM(S): Mus musculus 
2015-07-23 | E-GEOD-66055 | biostudies-arrayexpress
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