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ProteomicsTargeted KRAS(G12V) degradation elicits efficient and durable lung adenocarcinoma regression in vivo
Recent drug discovery breakthroughs led to the approval of KRASG12C inhibitors in lung adenocarcinoma (LUAD). Unfortunately, clinical responses remain limited due to rapid resistance onset. Proteolysis-targeting chimeras (PROTACs) have emerged as promising alternatives to traditional inhibition. How...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-13 | PXD058734 | Pride
Mouse models Targeted protein degradation in vivo Resistance Llung adenocarcinoma Kras Protacs 
UnknownModerately hypofractionated post-operative radiation therapy for breast cancer: Systematic review and meta-analysis of randomized clinical trials.
Not available
S-EPMC9073333 | biostudies-literature
ProteomicsSILAC-Based Proteomics of Primary Human Kidney Cells treated with Sex Hormones.
Male sex predispose to many kidney diseases. Considering that androgens exert deleterious effects in a variety of cell types within kidney, we hypothesized that dihydrotestosterone (DHT) would impair the biology of the renal tubular cell by inducing changes in the proteome. We employed stable isotop...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080854 | MassIVE
UnknownRelationship Between Severity of Ischemia and Coronary Artery Disease for Different Stress Test Modalities in the ISCHEMIA Trial.
Not available
S-EPMC11658795 | biostudies-literature
UnknownEarly short course of neuromuscular blocking agents in patients with COVID-19 ARDS: a propensity score analysis.
Not available
S-EPMC9112652 | biostudies-literature
UnknownCorrection : Epidemiology and outcomes of early-onset AKI in COVID-19-related ARDS in comparison with non-COVID-19-related ARDS: insights from two prospective global cohort studies.
Not available
S-EPMC10214330 | biostudies-literature
UnknownVariability of oxygen requirements in critically ill COVID-19 patients.
Not available
S-EPMC10884784 | biostudies-literature
UnknownFactors Associated With Coronary Angiography Performed Within 6 Months of Randomization to the Conservative Strategy in the ISCHEMIA Trial.
Not available
S-EPMC11187765 | biostudies-literature
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