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TranscriptomicsExploiting microRNA and mRNA profiles generated in vitro from carcinogen-exposed primary mouse hepatocytes for predicting in vivo genotoxicity and carcinogenicity (miRNA)
The well-defined battery of in vitro systems applied within chemical cancer risk assessment is often characterised by a high false-positive rate, thus repeatedly failing to correctly predict the in vivo genotoxic and carcinogenic properties of test compounds. Toxicogenomics, i.e. mRNA-profiling, has...
ORGANISM(S): Mus musculus 
2016-06-28 | E-GEOD-72014 | biostudies-arrayexpress
TranscriptomicsEvaluating microRNA profiles reveals discriminative responses following genotoxic or non-genotoxic carcinogen exposure in primary mouse hepatocytes [Exiqon]
The study investigated differential miRNA changes in primary mouse hepatocyte following 24 and 48 hours of exposure to aflatoxin B1, cisplatin, benzo(a)pyrene, 2,3,7,8-tetrachloordibenzo-p-dioxine, cyclosporin A or Wy-14,643 or their responsive solvent. Three (four for Wy-14,643) biological replica...
ORGANISM(S): Mus musculus 
2015-05-18 | E-GEOD-57082 | biostudies-arrayexpress
TranscriptomicsEvaluating microRNA profiles reveals discriminative responses following genotoxic or non-genotoxic carcinogen exposure in primary mouse hepatocytes [Affymetrix]
The study investigated differential gene expression in primary mouse hepatocyte mRNA following 24 and 48 hours of exposure to aflatoxin B1, cisplatin, benzo(a)pyrene, 2,3,7,8-tetrachloordibenzo-p-dioxine, cyclosporin A or Wy-14,643 or their responsive solvent. Three (four for Wy-14,643) biological ...
ORGANISM(S): Mus musculus 
2015-05-18 | E-GEOD-57129 | biostudies-arrayexpress
TranscriptomicsExploiting microRNA and mRNA profiles generated in vitro from carcinogen-exposed primary mouse hepatocytes for predicting in vivo genotoxicity and carcinogenicity (mRNA)
The well-defined battery of in vitro systems applied within chemical cancer risk assessment is often characterised by a high false-positive rate, thus repeatedly failing to correctly predict the in vivo genotoxic and carcinogenic properties of test compounds. Toxicogenomics, i.e. mRNA-profiling, has...
ORGANISM(S): Mus musculus 
2016-06-28 | E-GEOD-72081 | biostudies-arrayexpress
TranscriptomicsExploiting microRNA and mRNA profiles generated in vitro from carcinogen-exposed primary mouse hepatocytes for predicting in vivo genotoxicity and carcinogenicity
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2016-06-28 | E-GEOD-72088 | biostudies-arrayexpress
TranscriptomicsExpression Profiles of HepG2 cells treated with 7M-BM-5M of the genotoxic compound cisplatin
The transcriptomic changes induced in the human liver cell line HepG2 by 7M-BM-5M of cisplatin after treatment for 12, 24 and 48h The study investigated differential gene expression in HepG2 cell line mRNA following 12,24 and 48 hours of exposure to 7M-BM-5M of cisplatin and its solvent. Three biolo...
ORGANISM(S): Homo sapiens 
2013-12-05 | E-GEOD-38122 | biostudies-arrayexpress
TranscriptomicsCharacterization of cisplatin-induced transcriptomics responses in primary mouse hepatocytes, HepG2 cells and mouse embryonic stem cells shows a strong conservation of involved transcription factors
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-12-05 | E-GEOD-38124 | biostudies-arrayexpress
TranscriptomicsEvaluating mRNA and microRNA profiles reveals discriminative and compound-specific responses following genotoxic or non-genotoxic carcinogen exposure in primary mouse hepatocytes
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-05-18 | E-GEOD-57132 | biostudies-arrayexpress
TranscriptomicsExpression Profiles of PMH treated with 7M-BM-5M of the genotoxic compound cisplatin
The transcriptomic changes induced in primary mouse hepatocytes (C57BL/6 ) by 7M-BM-5M of cisplatin after treatment for 24 and 48h The study investigated differential gene expression in PMH mRNA following 24 and 48 hours of exposure to 7M-BM-5M of cisplatin and its solvent. Three biological replic...
ORGANISM(S): Mus musculus 
2013-12-05 | E-GEOD-38123 | biostudies-arrayexpress
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