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TranscriptomicsExpression data from Sh2b3 Knock-out NOTCH1-induced leukemias
To formally address the tumor suppressor activity of Sh2b3 in vivo, we tested the interaction between oncogenic NOTCH1 and Sh2b3 loss in a retroviral- transduction bone marrow transplantation model of NOTCH-induced T-ALL Forced expression of activated NOTCH1 in this model typically results in full l...
ORGANISM(S): Mus musculus 
2013-11-06 | E-GEOD-44025 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of Early immature and Late mature T-ALL cell lines
Early immature T-cell acute lymphoblastic leukemias (T-ALLs) account for about 5-10% of pediatric T-ALLs and are associated with poor prognosis. However, the genetic defects that drive the biology of these tumors remain largely unknown. Analysis of microarray gene expression signatures in adult T-AL...
ORGANISM(S): Homo sapiens 
2013-06-18 | E-GEOD-48046 | biostudies-arrayexpress
TranscriptomicsGene Expression Analyisis of T-ALL LOUCY cell lines treated with ETV6 siRNA vs. scramble control siRNA
Transcriptional effects of ETV6 inactivation in immature T-ALL were investigated by gene expression analysis upon siRNA-mediated knockdown of ETV6 in LOUCY cells, a T-ALL cell line with a transcriptional program highly related to that of immature T-ALLs. Gene Set Enrichment Analysis (GSEA) of the ET...
ORGANISM(S): Homo sapiens 
2011-11-24 | E-GEOD-33820 | biostudies-arrayexpress
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