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TranscriptomicsCompare gene expression profiles of mouse iNSC, WT-NSC, and MEF
The iNSC cells are two clones generated from the same MEF line. Therefore, we conducted one analysis that compared the two clonal lines and a separate analysis that compared iNSC vs. NSC, iNSC vs. MEF, and NSC vs. MEF. Both were single factor ANOVAs, the first compared two groups (the iNSC lines) ...
ORGANISM(S): Mus musculus 
2012-06-06 | E-GEOD-37859 | biostudies-arrayexpress
TranscriptomicsLarge inverted duplications form via a hairpin mechanism
Inverted duplications are a common type of copy number variation (CNV) in germline and somatic genomes. Large duplications that include many genes can lead to both neurodevelopmental phenotypes in children and gene amplifications in tumors. There are several models for inverted duplication formation...
ORGANISM(S): Homo sapiens 
2013-04-03 | E-GEOD-45395 | biostudies-arrayexpress
TranscriptomicsCollier/OLF/EBF-dependent transcriptional dynamics control muscle specification from cardiopharyngeal progenitors
In vertebrates, pluripotent pharyngeal mesoderm progenitors produce the cardiac precursors of the second heart field as well as the branchiomeric head muscles and associated stem cells. However, the cellular and molecular mechanisms underlying the transition from multipotent progenitors to distinct ...
ORGANISM(S): Ciona intestinalis 
2014-07-17 | E-GEOD-54746 | biostudies-arrayexpress
TranscriptomicsExpression profiling by high throughput sequencing (RNA sequencing)
RNAseq of CLDN6 sorted Epiblast Stem Cells (EpiSCs), WT vs Pbx1-KO lines in mouse embryonic stem cells (ES (2i/LIF and serum/LIF) and EpiSCs, as well as across differentiation (EpiSCs differentiated towards Posterior Primitive Streak (PPS) and Extraembryonic Mesoderm (ExM). Also EpiSCs treated with ...
ORGANISM(S): Mus musculus 
2024-11-29 | E-MTAB-13618 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of B7.5 lineage cells in the tunicate Ciona intestinalis to study cardiac cell migration
Eight different types of sample (three samples each) were used in this study of cardiac cell migration in the tunicate Ciona intestinalis. The B7.5 lineage cells were isolated by Fluorescent Activated Cell Sorting (FACS) at the tailbud stage, when the cardiac precursors (anterior B7.5 lineage cells)...
ORGANISM(S): Ciona intestinalis 
2008-06-01 | E-MEXP-1478 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of murine embryos lacking endogenous retinoic acid signaling
Retinoic acid (RA), an active derivative of the liposoluble vitamin A (retinol), acts as an important signaling molecule during embryonic development, regulating phenomenons as diverse as anterior-posterior axial patterning, forebrain and optic vesicle development, specification of hindbrain rhombom...
ORGANISM(S): Mus musculus 
2013-03-31 | E-GEOD-43578 | biostudies-arrayexpress
TranscriptomicsHedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma model
The Sonic Hedgehog (Shh) pathway drives a subset of medulloblastomas, a malignant neuroectodermal brain cancer, and other cancers. Small-molecule Shh pathway inhibitors have induced tumor regression in mice and patients with medulloblastoma; however, drug resistance rapidly emerges, in some cases vi...
ORGANISM(S): Mus musculus 
2012-04-19 | E-GEOD-37417 | biostudies-arrayexpress
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