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TranscriptomicsDownregulation of specific miRNAs in hyperdiploid multiple myeloma mimics the oncogenic effect of IgH translocations occurring in the non-hyperdiploid subtype
Currently, multiple myeloma (MM) patients are broadly grouped into a non-hyperdiploid Group (nh-MM), highly enriched for IgH translocations, or into a hyperdiploid Group (h-MM), which is typically characterized by trisomies of some odd-numbered chromosomes. We compared the miRNA expression profiles...
ORGANISM(S): Homo sapiens 
2013-12-03 | E-GEOD-40308 | biostudies-arrayexpress
TranscriptomicsGenomic Characterization of Bladder Cancer Cell Lines using CGH Arrays
Genomic rearrangements involving different chromosome translocation in bladder cancer cell lines and in primary tumor samples DNA extracted from 3 Bladder Cancer Cell lines (SW1710, JON, RT-4), and 1 bladder cancer (372C) in T3 Tumor stage and Grade 3 primary sample, were processed, Cy5 labeled and...
ORGANISM(S): Homo sapiens 
2013-06-28 | E-GEOD-30754 | biostudies-arrayexpress
GenomicsAberrant chromatin acetylation in MLL-AF9 leukemia mediates the response to HDAC inhibition (ChIP-Seq)
We studied the chromatin modification patterns induced by the presence of the MLL-AF9 fusion protein in a model of human hematopoietic stem/progenitor cells (HSPC) transduced with retrovirus expressing MLL-AF9cDNA (HSPC-MA9). Comparative ChIP-seq analysis between HSPC-MA9 and control HSPC, revealed ...
ORGANISM(S): Homo sapiens 
2015-03-01 | E-GEOD-54344 | biostudies-arrayexpress
TranscriptomicsAberrant chromatin acetylation in MLL-AF9 leukemia mediates the response to HDAC inhibition (microarray)
We investigated the response of acute myeloid cells (AML) expressing MLL-AF9 fusion gene to the pan-HDACi panobinostat (LBH589), and found that low conentrations of panobinostat lead to MLL-AF9 cell toxicity and rapid changes in gene expression. Human hematopoietic stem/progenitor cells (HSPC) expre...
ORGANISM(S): Homo sapiens 
2015-03-01 | E-GEOD-54218 | biostudies-arrayexpress
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