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TranscriptomicsSlicing-Independent RISC Activation Requires the Argonaute PAZ Domain
Small RNAs regulate the genetic networks through a ribonucleoprotein complex called the RNA induced silencing complexes (RISC), which in mammals contains at its center one of four Argonaute proteins (Ago1-4). A key regulatory event in the RNAi and miRNA pathways is Ago loading, where double stranded...
ORGANISM(S): Homo sapiens 
2012-07-12 | E-GEOD-39146 | biostudies-arrayexpress
TranscriptomicsDifferential RISC association of endogenous human microRNAs predicts their inhibitory potential
It has previously been assumed that the generally high stability of microRNAs (miRNAs) reflects their tight association with Argonaute (Ago) proteins, essential components of the RNA-induced silencing complex (RISC). However, recent data have suggested that the majority of mature miRNAs are not, in ...
ORGANISM(S): Homo sapiens 
2014-05-30 | E-GEOD-58127 | biostudies-arrayexpress
TranscriptomicsThe mRNA and microRNA expression profile of the RNA-induced silencing complex in human U-87 astrocytoma cells and primary human astrocytes
mRNA and microRNA expression was examined in global cellular fractions and in RNA-induced silencing complex (RISC)-immunoprecipitated cell fractions in cultured primary human astrocytes (ScienCell) and in cultured human U-87 MG astrocytoma cells (ATCC). ABSTRACT: Background: GW/P bodies are cytoplas...
ORGANISM(S): Homo sapiens 
2011-05-26 | E-GEOD-21514 | biostudies-arrayexpress
TranscriptomicsmRNA- and RISC-sequencing of mouse hearts overexpressing miR-133a
miR-133a-3p is a highly abundant cardiomyocyte-enriched microRNA whose expression is persistently decreased in response to pressure overload (or transverse aortic constriction, TAC) in mice. Overexpression of miR-133a in cardiomyocytes of mouse hearts in vivo (under the control of the Myh6 promoter)...
ORGANISM(S): Mus musculus 
2016-01-11 | E-GEOD-65141 | biostudies-arrayexpress
TranscriptomicsThe structure of human Argonaute-2 in complex with miR-20a
Argonaute proteins lie at the heart of the RNA-Induced Silencing Complex (RISC), wherein they use small RNA guides to recognize targets. Some Argonaute proteins can directly cleave their targets, whereas others recruit co-factors to repress independently of “slicing.” Prior studies established the a...
ORGANISM(S): Spodoptera frugiperda 
2012-05-12 | E-GEOD-37931 | biostudies-arrayexpress
GenomicsThe Integrator complex regulates microRNA abundance through RISC loading
The Integrator complex regulates microRNA abundance through RISC loading
PRJNA738965 | ENA
GenomicsCharacterization of the deregulation of the RNAs associated to the RISC complex in skeletal muscle of DM1 patients (RISC-IP small RNA)
Characterization of the deregulation of the RNAs associated to the RISC complex in skeletal muscle of DM1 patients (RISC-IP small RNA)
PRJNA427729 | ENA
GenomicsCharacterization of the deregulation of the RNAs associated to the RISC complex in skeletal muscle of DM1 patients (RISC-IP long RNA)
Characterization of the deregulation of the RNAs associated to the RISC complex in skeletal muscle of DM1 patients (RISC-IP long RNA)
PRJNA427750 | ENA
TranscriptomicsPARN mediates 3'-end trimming of Argonaute-cleaved precursor microRNAs
microRNAs (miRNAs) are typically generated as ~22-nucleotide double-stranded RNAs via processing of precursor hairpins by the RNase III enzyme Dicer, after which they are loaded into Argonaute (Ago) proteins to form RNA-induced silencing complex (RISC). However, the biogenesis of miR-451, an erythro...
ORGANISM(S): Danio rerio 
2013-11-13 | E-GEOD-51036 | biostudies-arrayexpress
Unknown3' fragment of miR173-programmed RISC-cleaved RNA is protected from degradation in a complex with RISC and SGS3.
Not available
S-EPMC3593843 | biostudies-literature
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