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GenomicsHistone methylation profiles of prospectively isolated mammary epithelial subpopulations
In this study we mapped H3K27me3, H3K4me3 and H3K9me2 marks in three mammary epithelial subsets: MaSC/basal (MS), luminal progenitor (LP) and mature luminal (ML) in the steady-state. In addition, profiles were generated for H3K4me3 and H3K27me3 marks in the MaSC/basal and luminal populations from th...
ORGANISM(S): Mus musculus 
2013-02-20 | E-GEOD-43212 | biostudies-arrayexpress
UnknownPolycythemia Vera: An Appraisal of the Biology and Management 10 Years After the Discovery of JAK2 V617F.
Not available
S-EPMC4979103 | biostudies-literature
TranscriptomicsMusashi 2 is a regulator of the hematopoietic stem cell compartment identified by a retroviral insertion screen and knockout mice
We have used a retroviral integration screen to search for novel genes that regulate hematopoietic stem cell (HSC) function. One of the genes that conferred HSC dominance when overexpressed due to an adjacent retroviral insertion was Musashi 2 (Msi2), an RNA binding protein that can act as a transla...
ORGANISM(S): Mus musculus 
2011-05-21 | E-GEOD-29432 | biostudies-arrayexpress
UnknownIntegrative epigenomics, transcriptomics and proteomics of patient chondrocytes reveal genes and pathways involved in osteoarthritis.
Not available
S-EPMC5566454 | biostudies-literature
TranscriptomicsRapid estrogen receptor signaling is essential for the protective effects of estrogen against vascular injury
Background: Clinical trial and epidemiological data support that the cardiovascular effects of estrogen are complex, including a mixture of both potentially beneficial and harmful effects. In animal models, estrogen protects females from vascular injury and inhibits atherosclerosis. These effects ar...
ORGANISM(S): Mus musculus 
2012-09-01 | E-GEOD-35558 | biostudies-arrayexpress
TranscriptomicsPervasive effects of an endophytic fungus on host genetic and phenotypic expression in a tropical tree (part 1)
Inoculation of endophyte-free (E-) Theobroma cacao leaves with Colletotrichum tropicale (E+), the dominant foliar fungal endophyte in healthy T. cacao, induced significant changes in the expression of hundreds of host genes. Further, E+ leaves exhibit enhanced pathogen resistance, increased lignin a...
ORGANISM(S): Theobroma cacao 
2014-06-30 | E-GEOD-54730 | biostudies-arrayexpress
UnknownSetdb1-mediated H3K9 methylation is enriched on the inactive X and plays a role in its epigenetic silencing.
Not available
S-EPMC4870784 | biostudies-literature
TranscriptomicsExpression profile of control, Drosha or Dicer deleted LSKs
To determine genes regulated independently of microRNAs in early haematopoietic progenitors (LSKs) we compared the expression profiles of Drosha or Dicer deficient LSKs and control. Those genes differentially expressed between Drosha or Dicer deficient LSKs are likely regulated indepedently of micro...
ORGANISM(S): Mus musculus 
2015-09-10 | E-GEOD-61305 | biostudies-arrayexpress
TranscriptomicsWhole-genome methylation profiling of monocytes and alveolar-like monocyte-derived macrophages from healthy controls and NSAID-exacerbated respiratory disease (N-ERD) patients
NSAID-exacerbated respiratory disease (N-ERD) represents a particularly severe endotype of chronic rhinosinusitis with nasal polyps (CRSwNP), which affects around 10-16% of CRSwNP patients. N-ERD is characterized by severe and refractory nasal polyposis, bronchial asthma and intolerance to non-stero...
ORGANISM(S): Homo sapiens 
2020-07-31 | E-MTAB-8065 | biostudies-arrayexpress
MetabolomicsComparative non-targeted LC-MS metabolomic profiling of murine bone marrow-derived macrophages cultured in 2D versus 3D

Macrophages are key drivers of inflammatory and fibrotic diseases and their activation is shaped by interactions in their tissue microenvironment. However, dissecting the processes that drive immunopathology has proved challenging as traditional 2D culture methods fail to capture the complex mole...

2026-06-08 | MTBLS12917 | MetaboLights
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