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TranscriptomicsPolyglutamine expanded huntingtin dramatically alters the genome-wide binding of HSF1 (mRNA)
In Huntington's disease (HD), polyglutamine expansions in the huntingtin (Htt) protein cause subtle changes in cellular functions that, over-time, lead to neurodegeneration and death. Studies have indicated that activation of the heat shock response can reduce many of the effects of mutant Htt in d...
ORGANISM(S): Mus musculus 
2012-06-18 | E-GEOD-38001 | biostudies-arrayexpress
TranscriptomicsMethylation profiling of Glioma Stem Cell lines vs GBM FFPE tissue biopsies and foetal Neural Stem Cell lines
The DNA methylation profiles of Glioma Stem Cell (GSC) lines were investigated in order to find the stem cell signature associated to glioblastoma (GBM). This goal was achieved through the comparison of GSC methylation data with FFPE-GBM biopsies and human foetal Neural Stem Cell (NSC) lines profile...
ORGANISM(S): Homo sapiens 
2013-03-08 | E-GEOD-41824 | biostudies-arrayexpress
TranscriptomicsGenome variation profiling of Glioma Stem Cell lines
Glioblastoma multiforme (GBM), the most common and malignant type of glioma, is characterized by a poor prognosis and the lack of an effective treatment, which are due to a small sub-population of cells with stem-like properties, termed glioma stem cells (GSCs). The term M-bM-^@M-^\multiformeM-bM-^@...
ORGANISM(S): Homo sapiens 
2013-03-08 | E-GEOD-41875 | biostudies-arrayexpress
GenomicsInsights into GATA-1-Mediated Gene Activation versus Repression via Genome-wide Chromatin Occupancy Analysis
The transcription factor GATA-1 is required for terminal erythroid maturation and functions as an activator or repressor depending on gene context. Yet its in vivo site selectivity and ability to distinguish between activated versus repressed genes remain incompletely understood. In this study, we p...
ORGANISM(S): Mus musculus 
2009-11-25 | E-GEOD-16594 | biostudies-arrayexpress
TranscriptomicsRNASET2-silenced and control OVCAR3 cell clones injected into nude mice.
To investigate the molecular pathways underlying RNASET2-mediated tumor suppression in vivo, we investigated the gene expression profile of tumor samples obtained from control and RNASET2-silenced OVCAR3 xenografts, respectively. In order to evaluate the contribution of human cancer cells and the...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-43029 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human skeletal muscle samples from mitochondrial disorder subjects
Extremely variable clinic and genetic features characterize Mitochondrial Encephalomyopathy Disorders (MED). Pathogenic mitochondrial DNA (mtDNA) defects can be divided into large-scale rearrangements and single point mutations. Clinical manifestations become evident when a threshold percentage of t...
ORGANISM(S): Homo sapiens 
2007-08-04 | E-GEOD-1462 | biostudies-arrayexpress
TranscriptomicsPolyglutamine expanded huntingtin dramatically alters the genome-wide binding of HSF1
This SuperSeries is composed of the following subset Series: GSE38000: Polyglutamine expanded huntingtin dramatically alters the genome-wide binding of HSF1 (ChIP-Seq) GSE38001: Polyglutamine expanded huntingtin dramatically alters the genome-wide binding of HSF1 (mRNA) Refer to individual Series
ORGANISM(S): Mus musculus 
2012-06-18 | E-GEOD-38002 | biostudies-arrayexpress
GenomicsPolyglutamine expanded huntingtin dramatically alters the genome-wide binding of HSF1 (ChIP-Seq)
In HuntingtonM-bM-^@M-^Ys disease (HD), polyglutamine expansions in the huntingtin (Htt) protein cause subtle changes in cellular functions that, over-time, lead to neurodegeneration and death. Studies have indicated that activation of the heat shock response can reduce many of the effects of mutan...
ORGANISM(S): Mus musculus 
2012-06-19 | E-GEOD-38000 | biostudies-arrayexpress
UnknownRole of the repeat expansion size in predicting age of onset and severity in RFC1 disease.
Not available
S-EPMC11068103 | biostudies-literature
UnknownGlobal anaesthesia practice using inguinal hernia surgery as a tracer condition: a secondary analysis of an international prospective cohort study.
Not available
S-EPMC12519944 | biostudies-literature
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