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TranscriptomicsPredominance of MAPK reactivation in early resistance to debrafenib/trametinib combination therapy of BRAF mutant metastatic melanoma.
One third of BRAF-mutant metastatic melanoma patients treated with combined BRAF and MEK inhibition progress within six months. Treatment options for these patients remain limited. Here we analyse twenty BRAFV600 mutant melanoma metastases derived from 10 patients treated with the combination of deb...
ORGANISM(S): Homo sapiens 
2014-12-03 | E-GEOD-61992 | biostudies-arrayexpress
UnknownUnexpected excessive apixaban exposure: case report of a patient with polymorphisms of multiple apixaban elimination pathways.
Not available
S-EPMC6716843 | biostudies-literature
TranscriptomicsSex-related transcriptional differences in Day 7 bovine in vitro produced blastocysts
Sexual dimorphism in mammals is mostly attributable to sex-related hormonal differences in fetal and adult tissues; however, this may not be the sole determinant. Though genetically-identical for autosomal chromosomes, male and female preimplantation embryos could display sex-specific transcriptiona...
ORGANISM(S): Bos taurus 
2010-03-09 | E-GEOD-17921 | biostudies-arrayexpress
TranscriptomicsSpectrum, clinical correlates and clinical implications of BRAF-inhibitor resistance mechanisms in melanoma
Multiple BRAF inhibitor resistance mechanisms have been described, however their relative frequency, clinical correlates, and effect on subsequent therapy have not been assessed in patients with metastatic melanoma. Excised progressing BRAFV600 mutant melanoma metastases (Prog) from patients treated...
ORGANISM(S): Homo sapiens 
2014-02-19 | E-GEOD-50509 | biostudies-arrayexpress
UnknownThe relative contributions of the p53 and pRb pathways in oncogene-induced melanocyte senescence.
Not available
S-EPMC2806033 | biostudies-literature
TranscriptomicsOviduct-Embryo Interactions in Cattle: Two-Way Traffic or a One-Way Street? [Affymetrix]
The objective of this study was to examine the effect of the presence of a single or multiple embryo(s) on the transcriptome of the bovine oviduct. In Experiment 1, cyclic (non-bred, n = 6) and pregnant (artificially inseminated, n = 11) heifers were slaughtered on Day 3 after estrus, and the ampull...
ORGANISM(S): Bos taurus 
2015-11-04 | E-GEOD-74593 | biostudies-arrayexpress
TranscriptomicsAnti-proliferative effects of continued mitogen activated protein kinase pathway inhibition following acquired resistance to BRAF and/or MEK inhibition in melanoma: Implications for treatment beyond disease progression
Inhibitors of the MAPKs, BRAF and MEK, induce tumor regression in the majority of patients with BRAF-mutant metastatic melanoma. The clinical benefit of MAPK inhibitors is restricted by the development of acquired resistance with half of those who benefit having progressed by 6-7 months and long-ter...
ORGANISM(S): Homo sapiens 
2013-06-30 | E-GEOD-44753 | biostudies-arrayexpress
UnknownThe impact of two different transfusion strategies on patient immune response during major abdominal surgery: a preliminary report.
Not available
S-EPMC3996304 | biostudies-literature
UnknownSex determines the expression level of one third of the actively expressed genes in bovine blastocysts.
Not available
S-EPMC2840439 | biostudies-literature
UnknownHaemorrhagic Transformation after Ischaemic Stroke in Patients Taking Non-vitamin K Antagonist Oral Anticoagulants.
Not available
S-EPMC5307942 | biostudies-literature
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