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TranscriptomicsDetermination of the protein interactome of the transcription factor Sox2 in embryonic stem cells engineered for inducible expression of four reprogramming factors
Coordinate expression of the somatic cell reprogramming factors Oct4, Sox2, Klf4 and c-Myc within embryonic stem cells preserves the self-renewal of these cells, while allowing for the expression epitope tagged Sox2. Taking advantage of this observation, we engineered embryonic stem cells (i-OSKM-ES...
ORGANISM(S): Mus musculus 
2012-02-20 | E-GEOD-34801 | biostudies-arrayexpress
UnknownElevating Sox2 levels deleteriously affects the growth of glioblastoma and medulloblastoma cells
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-36947 | biostudies-other
TranscriptomicsElevating Sox2 levels deleteriously affects the growth of glioblastoma and medulloblastoma cells.
Induction of the transcription factor Sox2 from a doxycycline-inducible promoter in iSox2-DAOY medulloblastoma cells. Affymetrix microarrays were used to characterize the gene expression profile of iSox2-DAOY cells in the absence and presence of doxycycline. Human DAOY medulloblastoma cells were eng...
ORGANISM(S): Homo sapiens 
2012-08-25 | E-GEOD-36947 | biostudies-arrayexpress
TranscriptomicsMusashi2 is required for the self-renewal and pluripotency of embryonic stem cells
Recent studies have shown that the RNA binding protein Musashi 2 (Msi2) plays prominent roles during development and leukemia. Additionally, in embryonic stem cells (ESC) undergoing the early stages of differentiation, Msi2 has been shown to associate with Sox2, which is required for the self-renewa...
ORGANISM(S): Mus musculus 
2012-08-25 | E-GEOD-33882 | biostudies-arrayexpress
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