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MetabolomicsMetabolomic study of disease progression in scrapie prion infected (RML) mice
Not available
ORGANISM(S): Mus musculus 
ST001291 | MetabolomicsWorkbench
TranscriptomicsExpression data from C2C12 myotubes infected with RML prions
Prion infection in animals results in neurodegeneration and eventually death. To examine the cellular impact of Prion disease, we profiled non-proliferative fully differentiated C2C12 cells, which can replicate prions to high levels. Results suggest that accumulation of high levels of PrPSc in C2C12...
ORGANISM(S): Mus musculus 
2013-12-22 | E-GEOD-44563 | biostudies-arrayexpress
TranscriptomicsTime course of prion infected (RML) and globular domain ligands (POM1) in cultured organotypic cerebellar slices (COCS)
Cultured organotypic cerebellar slices were exposed for different time points with either prions (RML) versus non-infectious brain homogenate (NBH) or ligands to the globular domain of the prion protein (POM1) vs IgG We used microarrays to characterize the temporal response of two inducers prion pro...
ORGANISM(S): Mus musculus 
2015-01-22 | E-GEOD-65147 | biostudies-arrayexpress
TranscriptomicsRML Prion and mock-infected murine neuroblastoma cells
Affymetrix genechip profiling analsysis (MOE430A and MOE430B) of murine neuroblastoma cells infected with either RML prion strain or mock brain homogenate Keywords: Affymetrix gene expression profiling
ORGANISM(S): Mus musculus 
2008-02-25 | GSE7229 | GEO
TranscriptomicsPreclinical CNS changes following peripheral murine RML prion challenge
Mice were challenged with either RML prions or mock brain homogenate intraperitoneally. Whole brains were harvested and processed at 145 days post-inoculation, with mice reaching terminal stages of disease in this model at approximately 200 days post-inoculation. Keywords: Transcriptional profiling
ORGANISM(S): Mus musculus 
2008-07-01 | GSE7207 | GEO
UnknownCryo-EM structure of anchorless RML prion reveals variations in shared motifs between distinct strains.
Not available
S-EPMC9279418 | biostudies-literature
GenomicsRickettsia bellii str. RML Mogi
Sequencing Rickettsiales Genomes
PRJNA212474 | ENA
GenomicsRickettsia bellii str. RML An4
Sequencing Rickettsiales Genomes
PRJNA212473 | ENA
TranscriptomicsTime course of prion infected (RML) and globular domain ligands (POM1) in cultured organotypic cerebellar slices (COCS)
Cultured organotypic cerebellar slices were exposed for different time points with either prions (RML) versus non-infectious brain homogenate (NBH) or ligands to the globular domain of the prion protein (POM1) vs IgG
ORGANISM(S): Mus musculus 
2015-01-22 | GSE65147 | GEO
TranscriptomicsTranscriptomic Responses to Prion Disease in Rats
While prion infections have been extensively characterized in the laboratory mouse, little is known regarding the molecular responses to prions in other rodents. To explore these responses and make comparisons, we generated a prion disease in the laboratory rat by successive passage of mouse RML pri...
ORGANISM(S): Rattus norvegicus 
2015-09-01 | E-GEOD-63930 | biostudies-arrayexpress
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