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MetabolomicsAntioxidant Activity, Phytochemical Profiling by UPLC-QTOF-MS, and In Silico Targeting of the RNA-Binding Protein DRBD18 of Trypanosoma brucei by Bioactive Compounds from Tetradenia riparia and Tetracera poggei
Oxidative stress plays a key role in the pathogenesis of African trypanosomiasis, and plant-derived antioxidants represent a promising source of dual-action compounds capable of both scavenging reactive oxygen species and interfering with parasite survival. The present study investigates the antioxi...
2026-09-10 | MTBLS15597 | MetaboLights
UnknownRNA encoded peptide barcodes enable efficient in vivo screening of RNA delivery systems.
Not available
S-EPMC11381334 | biostudies-literature
ProteomicsRNA Encoded Peptide Barcodes Enable Efficient in vivo Screening of RNA Delivery Systems
LNPs have been demonstrated to hold great promise for the clinical advancement of RNA therapeutics. Continued exploration of LNPs for application in new disease areas requires identification and optimisation of leads in a high throughput way. Currently available high throughput in vivo screening pla...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD053797 | Pride
Lnp Proteomics Rna In vivo High throughput Barcodes 
TranscriptomicsApelin-VEGF-C mRNA delivery as therapeutic for the treatment of secondary lymphedema
Secondary lymphedema (LD) corresponds to a severe lymphatic dysfunction leading to the accumulation of fluid and fibrotic adipose tissue in a limb. Here, we identified apelin (APLN) as a powerful molecule for regenerating lymphatic function in LD. We identified the loss of APLN expression in lymphed...
ORGANISM(S): Homo sapiens 
2023-10-20 | E-MTAB-13381 | biostudies-arrayexpress
ProteomicsTumor Agnostic Drug Delivery with Dynamic Nanohydrogels
RNA interference (RNAi) holds unique potential as a clinically viable modality to pharmacologically regulate oncogenes in sequence-specific manner. However, systemic delivery of RNAi to tumors encounters myriad obstructions, and strategies to overcome such barriers have largely consisted of academic...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-01-12 | PXD070605 | Pride
Nanohydrogels Rnai Plasma Drug delivery 
UnknownNon-viral vectors for RNA delivery.
Not available
S-EPMC8743282 | biostudies-literature
ProteomicsCompetitive Binding and Molecular Crowding Regulate the Cytoplasmic Interactome of Non-Viral Polymeric Gene Delivery Vectors
In contrast to the processes controlling the complexation, targeting and uptake of polycationic gene delivery vectors, the molecular mechanisms regulating their cytoplasmic dissociation remains poorly understood. Upon cytosolic entry, vectors become exposed to a complex, concentrated mixture of mole...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD028512 | Pride
Gene delivery Rna delivery Polymer brush Proteomics Cytosolic interactome Polycationic vector Lc-ms/ms 
GenomicsUsing an RNA-binding antibody for tumor-directed immunogenic RNA delivery
Using an RNA-binding antibody for tumor-directed immunogenic RNA delivery
PRJNA1232670 | ENA
GenomicsRNA delivery to the corneal endothelium using charge-altering releasable transporters
RNA delivery to the corneal endothelium using charge-altering releasable transporters
PRJNA1256295 | ENA
TranscriptomicsMicroRNAs are Transported in Plasma and Delivered to Recipient Cells by High-Density Lipoproteins (HG-U133 2.0)
Circulating microRNAs (miRNA) are relatively stable in plasma and are a new class of disease biomarkers. Here we present evidence that human high-density lipoprotein (HDL) transports endogenous miRNAs and delivers them to recipient cells with functional targeting capabilities. Highly-purified fracti...
ORGANISM(S): Homo sapiens 
2011-03-24 | E-GEOD-25311 | biostudies-arrayexpress
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