Sort   by:  
 Page size 
TranscriptomicsALKBH5 is a New Mammalian RNA Demethylase
N6-methyladenosine (m6A) is the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Here we report ALKBH5 as a new mammalian demethylase that oxidatively removes the m6A modification in mRNA in vitro and inside cells. This demethylation activity of ALKBH5 significantly...
ORGANISM(S): Mus musculus 
2013-02-15 | E-GEOD-40132 | biostudies-arrayexpress
GenomicsCpG islands recruit a histone H3 lysine 36 demethylase [Illumina sequencing data]
Eukaryotic gene expression profiles are largely defined by transcription factors that recognize specific DNA sequences in gene regulatory regions and impact RNA polymerase recruitment and transcription. In addition to specific core promoter regulatory elements, up to 70% of genes in higher eukaryote...
ORGANISM(S): Mus musculus 
2010-04-27 | E-GEOD-18588 | biostudies-arrayexpress
GenomicsCpG islands recruit a histone H3 lysine 36 demethylase
This SuperSeries is composed of the following subset Series: GSE18588: CpG islands recruit a histone H3 lysine 36 demethylase [Illumina sequencing data] GSE21201: CpG islands recruit a histone H3 lysine 36 demethylase [Agilent data] Refer to individual Series
ORGANISM(S): Homo sapiens 
2010-04-26 | E-GEOD-21202 | biostudies-arrayexpress
TranscriptomicsRole of the histone demethylase KDM2B in hematopoietic homeostasis and malignancies [RNA-seq]
Development of the hematopoietic system is dynamically controlled by the interplay of transcriptional and epigenetic networks to determine cellular identity. Those networks are critical for homeostasis and frequently dysregulated in leukemias. We identified histone demethylase Kdm2b as a critical re...
ORGANISM(S): Mus musculus 
2016-02-22 | E-GEOD-70728 | biostudies-arrayexpress
GenomicsInhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia
This SuperSeries is composed of the following subset Series: GSE34672: Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia [Illumina HumanHT-12 gene expression array] GSE34725: Inhibition of the LSD1 (KDM1A) demethylase...
ORGANISM(S): Homo sapiens 
2012-03-14 | E-GEOD-34726 | biostudies-arrayexpress
TranscriptomicsThe S. cerevisiae histone demethylase Jhd1 fine-tunes the distribution of H3K36me2
Histone methylation plays important roles in the regulation of chromatin dynamics and transcription. Steady state levels of histone lysine methylation are regulated by a balance between enzymes that catalyze either the addition or removal of methyl groups. Using an activity-based biochemical approac...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-11 | E-GEOD-7627 | biostudies-arrayexpress
GenomicsRole of the histone demethylase KDM2B in hematopoietic homeostasis and malignancies [ChIP-seq]
Development of the hematopoietic system is dynamically controlled by the interplay of transcriptional and epigenetic networks to determine cellular identity. Those networks are critical for homeostasis and frequently dysregulated in leukemias. We identified histone demethylase Kdm2b as a critical re...
ORGANISM(S): Homo sapiens 
2016-02-22 | E-GEOD-70624 | biostudies-arrayexpress
TranscriptomicsIBM1, a JmjC domain histone demethylase, is involved in the regulation of RNA-directed DNA methylation through epigenetic control of RDR2 and DCL3 expression in Arabidopsis.
The small RNA mediated DNA methylation (RdDM) is highly elaborated in Arabidopsis as an important epigenetic pathway controls expression of genes and multiple developmental processes. RDR2 and DCL3 are necessary factors to the 24-nt siRNA biogenesis and the RdDM pathway. Here, we find that IBM1 (inc...
ORGANISM(S): Arabidopsis thaliana 
2012-08-03 | E-GEOD-32284 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse primary embryonic fibroblasts reveals the retinoblastoma binding protein RBP2 is an H3K4 demethylase
The roles of histone demethylase RBP2 in gene expression were assessed using gene expression profiling experiments with wild type and RBP2-/- primary MEFs. Several cytokine genes including SDF1 and Kit ligand were upregulated upon inactivation of RBP2. Experiment Overall Design: Total RNA were extr...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6945 | biostudies-arrayexpress
GenomicsHistone Demethylase Lsd1 is Required to Repress Hematopoietic Stem and Progenitor Cell Signatures During Blood Cell Maturation
Here we describe that lysine-specific demethylase 1 (Lsd1/KDM1a), which demethylates histone H3 on LysM-bM-^@M-^I4 or LysM-bM-^@M-^I9 (H3K4/K9), is an indispensible epigenetic governor of hematopoietic differentiation. Integrative genomic analysis in primary hematopoietic cells, combining global occ...
ORGANISM(S): Mus musculus 
2013-06-25 | E-GEOD-40440 | biostudies-arrayexpress
Sort   by:  
 Page size