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ProteomicsAngel2 phosphatase activity is required for non-canonical mitochondrial RNA processing
Canonical RNA processing in mammalian mitochondria is defined by tRNAs acting as recognition sites for nucleases to release flanking transcripts. The relevant factors, their structures, and mechanism are well described, but not all mitochondrial transcripts are punctuated by tRNAs, and their mode of...
ORGANISM(S): Mus musculus (Mouse) Drosophila melanogaster (Fruit fly) 
2022-09-01 | PXD033394 | Pride
Angel2 Mitochondria Processing Mouse Rna Drosophila 
ProteomicsTEFM regulates both transcription elongation and RNA processing in mitochondria
Regulation of replication and expression of mitochondrial DNA (mtDNA) is essential for cellular energy conversion via oxidative phosphorylation. The mitochondrial transcription elongation factor (TEFM) has been proposed to regulate the switch between transcription termination for replication primer ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-04-25 | PXD013398 | Pride
Mtdna replication Rna processing Transcription elongation 
TranscriptomicsMechanism for full-length RNA processing over intragenic heterochromatin
Mechanism for full-length RNA processing over intragenic heterochromatin
ORGANISM(S): Arabidopsis thaliana 
2014-04-22 | E-MTAB-4475 | biostudies-arrayexpress
GenomicsCBX3 Regulates Efficient RNA Processing Genome Wide
HP1 alpha, beta, and gamma play an evolutionarily conserved role in the formation and maintenance of heterochromatin. In addition, some HP1 family members may also participate in transcriptional regulation of genes. Recently, HP1 gamma binding to the bodies of a subset of genes has been observed in ...
ORGANISM(S): Homo sapiens 
2012-05-24 | E-GEOD-28115 | biostudies-arrayexpress
ProteomicsCoordination of nuclear RNA processing by speckle-localized kinase TAOK2
Nuclear speckles are membraneless organelles that act as active splicing hubs especially at sites of high transcription; emerging views of this dynamic subnuclear structure place it as a hub of RNA processing from transcription to export. To manage a complex microcosm of RNA metabolism, nuclear spec...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD069089 | Pride
Phosphoproteome Speckle-localized kinase taok2 Nuclear rna processing 
ProteomicsMulti-omic profiling reveals an RNA processing rheostat that predisposes to prostate cancer
Prostate cancer is the most commonly diagnosed malignancy and the second leading cause of cancer deaths in men. GWAS studies have identified variants associated with prostate cancer susceptibility, however, mechanistic and functional validation of these mutations are lacking. Mitochondrial energy me...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-19 | PXD033891 | Pride
Rna processing Dia Mitochondria Gene expression Prostate cancer susceptibility 
TranscriptomicsMitochondrial unfolded protein response controls matrix pre-RNA processing and translation
The mitochondrial matrix is unique in that it must integrate folding and assembly of proteins derived from nuclear and mitochondrial genomes. In C. elegans, the mitochondrial unfolded protein response (UPRmt) senses matrix protein misfolding and induces a program of nuclear gene expression, includin...
ORGANISM(S): Homo sapiens 
2016-06-28 | E-GEOD-75247 | biostudies-arrayexpress
TranscriptomicsMitochondrial unfolded protein response controls matrix pre-RNA processing and translation
The mitochondrial matrix is unique in that it must integrate folding and assembly of proteins derived from nuclear and mitochondrial genomes. In C. elegans, the mitochondrial unfolded protein response (UPRmt) senses matrix protein misfolding and induces a program of nuclear gene expression, includin...
ORGANISM(S): Homo sapiens 
2016-06-28 | E-GEOD-75410 | biostudies-arrayexpress
ProteomicsPCID2 regulates HIV-1 transcription and viral RNA processing during latency
HIV-1 latency results from a combination of tightly regulated molecular processes that act at distinct steps of HIV-1 gene expression. In an effort to elucidate the molecular players that govern viral latency, we previously performed a dCas9 chromatin immunoprecipitation coupled with mass spectromet...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD043334 | Pride
Pcid2 regulates hiv-1 transcription and viral rna processing during latency 
TranscriptomicsNSun2-mediated cytosine-5 methylation in Vault non-coding RNA determines its processing into small RNAs [iCLIP]
Autosomal-recessive loss of the NSUN2 gene has been recently identified as a causative link to intellectual disability disorders in humans. NSun2 is an RNA methyltransferase modifying cytosine-5 in transfer RNAs (tRNA). Whether NSun2 methylates additional RNA species is currently debated. Here, we a...
ORGANISM(S): Homo sapiens 
2013-07-23 | E-GEOD-44385 | biostudies-arrayexpress
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