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TranscriptomicsA nuclear Argonaute promotes germline immortality and epigenetic inheritance across generations
dsRNA-mediated gene silencing (RNAi) can be inherited for multiple generations in C. elegans. To understand this process we conducted a genetic screen for animals defective for transmitting RNAi silencing signals to future generations. This screen identified the gene heritable RNAi defective (hrde)-...
ORGANISM(S): Caenorhabditis elegans 
2012-07-30 | E-GEOD-38041 | biostudies-arrayexpress
GenomicsA cytoplasmic Argonaute protein promotes the inheritance of RNAi
A cytoplasmic Argonaute protein promotes the inheritance of RNAi
PRJNA447866 | ENA
TranscriptomicsRNAi promotes heterochromatic silencing through replication-coupled release of RNA pol II (RNA seq)
Heterochromatin comprises tightly compacted repetitive regions of eukaryotic chromosomes. The inheritance of heterochromatin through mitosis requires RNA interference (RNAi), which guides histone modification during the DNA replication phase of the cell cycle. Here, we show that the alternating arra...
ORGANISM(S): Schizosaccharomyces pombe 
2011-07-21 | E-GEOD-30827 | biostudies-arrayexpress
GenomicsRNAi promotes heterochromatic silencing through replication-coupled release of RNA pol II (ChIP-seq)
Heterochromatin comprises tightly compacted repetitive regions of eukaryotic chromosomes. The inheritance of heterochromatin through mitosis requires RNA interference (RNAi), which guides histone modification 1 during the DNA replication phase of the cell cycle2. Here, we show that the alternating a...
ORGANISM(S): Schizosaccharomyces pombe 
2011-07-29 | E-GEOD-31016 | biostudies-arrayexpress
GenomicsThe RNAi Inheritance Machinery of Caenorhabditis elegans
Gene silencing mediated by dsRNA (RNAi) can persist for multiple generations in C. elegans (termed RNAi inheritance). Here we describe the results of a forward genetic screen in C. elegans that has identified six factors required for RNAi inheritance: GLH-1/VASA, PUP-1/CDE-1, MORC-1, SET-32, and two...
ORGANISM(S): Caenorhabditis elegans 
2017-06-20 | GSE92840 | GEO
UnknownThe RNAi Inheritance Machinery of Caenorhabditis elegans.
Not available
S-EPMC5500139 | biostudies-literature
GenomicsA cytoplasmic Argonaute protein promotes the inheritance of RNAi
RNAi-elicited gene silencing is heritable and can persist for multiple generations after its initial induction in C. elegans. However, the mechanism by which parental-acquired trait-specific information from RNAi is inherited by the progenies is not fully understood. Here, we identified a cytoplasmi...
ORGANISM(S): Caenorhabditis elegans 
2018-04-28 | GSE112475 | GEO
UnknownA genetic framework for RNAi inheritance in Caenorhabditis elegans.
Not available
S-EPMC12373942 | biostudies-literature
TranscriptomicsTransgenerational inheritance of an acquired small RNA-based antiviral response in C.elegans
Deep sequencing was used to detect Flock House Virus (FHV)-derived small RNAs (viRNAs) that were inherited over generations. Small RNA libraries were constructed from 4 different samples: (a) FR1gfp-transgenic worms that can mount an RNAi response and should contain viRNAs (positive control); (b) rd...
ORGANISM(S): Caenorhabditis elegans 
2011-10-31 | E-GEOD-33334 | biostudies-arrayexpress
GenomicsCaenorhabditis elegans
The RNAi Inheritance Machinery of Caenorhabditis elegans
PRJNA358605 | ENA
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