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TranscriptomicsIdentification of RNAs that are physically and functionally associated with RNase P
Numerous RNAs copurify with RNase P and are affected by temperture sensitive mutations in conserved residues with the essential RNA and protein subunits. Specifically, RNase P physically interacts with ribosomal protein mRNAS and the intron-encoded box C/D snoRNAs. Keywords: RNA copurification, tem...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-01 | E-GEOD-10514 | biostudies-arrayexpress
TranscriptomicsAccumulation of noncoding RNA due to an RNase P defect in Saccharomyces cerevisiae
To investigate the possible range of additional RNase P substrates in vivo a strand-specific, high-density microarray was used to analyze what RNA accumulates with a mutation in the catalytic RNA subunit of nuclear RNase P in Saccharomyces cerevisiae. A wide variety of noncoding RNAs were shown to a...
ORGANISM(S): Saccharomyces cerevisiae 
2011-08-29 | E-MEXP-3140 | biostudies-arrayexpress
TranscriptomicsRNase G complementation of rne null mutation identifies functional interrelationships with RNase E
The Escherichia coli endoribonucleases RNase E (Rne) and RNase G (Rng) have sequence similarity and broadly similar sequence specificity. Whereas the absence of Rne normally is lethal, we show here that E. coli bacteria that lack the rne gene can be made viable by overexpression of Rng. Rng-compleme...
ORGANISM(S): Escherichia coli 
2005-08-13 | E-GEOD-3123 | biostudies-arrayexpress
ProteomicsHow a tRNA modifying enzyme facilitates RNase P activity in Arabidopsis nuclei
RNase P is essential to perform the 5’ maturation of tRNA precursors. Beyond the ancestral form of RNase P containing a ribozyme, protein-only RNase P enzymes termed PRORP were identified in eukaryotes. In human mitochondria, PRORP forms a complex with two protein partners to become functional. In p...
ORGANISM(S): Nicotiana benthamiana 
2023-10-20 | PXD040022 | Pride
Prorp interactome Arabidopsis Rna modifications Trna biogenesis Rnase p 
TranscriptomicsTranscription profiling of E. coli mutants lacking the rne gene and over expressing Rng
The Escherichia coli endoribonucleases RNase E (Rne) and RNase G (Rng) have sequence similarity and broadly similar sequence specificity. Whereas the absence of Rne normally is lethal, we show here that E. coli bacteria that lack the rne gene can be made viable by overexpression of Rng. Rng-compleme...
ORGANISM(S): Escherichia coli 
2005-07-11 | E-SMDB-1515 | biostudies-arrayexpress
GenomicsGenome-wide distribution of RNA-DNA hybrids identifies RNase H targets in tRNA genes, retrotransposons and mitochondria
During transcription the nascent RNA can invade the DNA template, forming extended RNA-DNA duplexes (R-loops). Here we employ ChIP-seq in strains expressing or lacking RNase H to map targets of RNase H activity throughout budding yeast genome. In wild-type strains, R-loops were readily detected over...
ORGANISM(S): Saccharomyces cerevisiae 
2014-11-03 | E-GEOD-53420 | biostudies-arrayexpress
GenomicsA tRNA modifying enzyme facilitates RNase P activity in Arabidopsis nuclei
A tRNA modifying enzyme facilitates RNase P activity in Arabidopsis nuclei
PRJNA928711 | ENA
TranscriptomicsGene expression profiling of constitutively competent comR and proQ mutants and RNase R (rnr) mutant of L. pneumophila
Bacterial competence is a genetically programmed process that is triggered as a response to environmental stimuli. DNA uptake from the extracellular milieu by competence requires the expression of a complex machinery composed of a competence pseudopilus and a DNA translocase. In L. pneumophila, it ...
ORGANISM(S): Legionella pneumophila 
2010-05-20 | E-GEOD-12796 | biostudies-arrayexpress
ProteomicsC18orf21/RMP24 and Nepro/RMP64 are RNase MRP-specific subunits required for 40S ribosome biogenesis
RNase MRP and RNase P are evolutionarily related complexes that facilitate rRNA and tRNA biogenesis, respectively. The two enzymes share nearly all protein subunits and have evolutionarily related catalytic RNAs. Notably, RNase P includes a unique subunit, RPP21, whereas no RNase MRP-specific protei...
ORGANISM(S): Homo sapiens (Human) 
2025-10-23 | PXD065571 | Pride
Rnase p Rnase mrp Rrna biogenesis 
TranscriptomicsTranscriptome of Sinorhizobium meliloti RNase mutants
The ribonucleases (RNases) E and J are essential in Escherichia coli and Bacillus subtilis, respectively. Sinorhizobium meliloti contains both, the rne gene encoding RNase E and the rnj gene encoding RNase J. The transcriptomes of the S. meliloti Rm2011 wild type, and rne and rnj mutants were compar...
ORGANISM(S): Sinorhizobium meliloti 
2017-01-21 | E-MTAB-5435 | biostudies-arrayexpress
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