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A long form (tRNase ZL) of tRNA 3' processing endoribonuclease (tRNase Z, or 3' tRNase) can cleave any target RNA at any desired site under the direction of artificial small guide RNA (sgRNA). We discovered in human kidney 293 cell extracts various new small noncoding RNAs (ncRNAs) including 5'-half...
ORGANISM(S): Homo sapiens 
RNase P is essential to perform the 5’ maturation of tRNA precursors. Beyond the ancestral form of RNase P containing a ribozyme, protein-only RNase P enzymes termed PRORP were identified in eukaryotes. In human mitochondria, PRORP forms a complex with two protein partners to become functional. In p...
ORGANISM(S): Nicotiana benthamiana 
2023-10-20 | PXD040022 | Pride
ELAC1 selectively trims vault RNA 3′ ends, revealing substrate partitioning between human RNase Z paralogs
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