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UnknownCombining targeted therapy with immunotherapy in BRAF-mutant melanoma: promise and challenges.
Not available
S-EPMC4164812 | biostudies-literature
TranscriptomicsImproved antitumor activity of immunotherapy combined with BRAF and MEK inhibitors in BRAFV600E mutant melanoma
The first clinical trial testing the combination of targeted therapy with a BRAF inhibitor vemurafenib and immunotherapy with a CTLA-4 antibody ipilimumab was terminated early due to significant liver toxicities, possibly due to paradoxical activation of the MAPK pathway by BRAF inhibitors in tumors...
ORGANISM(S): Mus musculus 
2014-12-12 | E-GEOD-64102 | biostudies-arrayexpress
GenomicsDAC for Sardinia FACS pilot project
Data Access Committee EGAC00001000132
EGAC00001000132 | EGA
GenomicsA sequence-based genetic dissection of human immune cell types and implications for immune-related disease.
The immune system is an intricate biological network mediating interactions with other organisms while preserving the integrity of our tissues. By mounting appropriate responses it protects us from a vast range of pathogens while inadvertent immune system attacks on self result in autoimmune disease...
EGAS00001000574 | EGA
Genomicsena-DATASET-irgb_cnr-28-08-2013-10:23:38:586-273 - samples
FACS phenotype of 1629 Sardinian samples
EGAD00001000656 | EGA
TranscriptomicsMitochondrial carrier SLC25A34 links clock, diet, and temperature control of adipocyte lipid cycling
BAT transcriptome from control and brown adipocyte-specific Rev-erbα/β double knockout mice housed at thermoneutrality or cold-challenged for 6 hours. Brown adipose tissue (BAT) samples were collected from control and brown adipocyte-specific Rev-erbα/β double knockout mice (Ucp1-Cre; Nr1d1/2 fl/fl)...
ORGANISM(S): Mus musculus 
2026-09-23 | E-MTAB-17580 | biostudies-arrayexpress
TranscriptomicsMitochondrial carrier SLC25A34 links clock, diet, and temperature control of adipocyte lipid cycling
Transcriptome from immortalized murine brown adipocytes BMC. Cells were transfected with siRNA construct #1 or construct #2 (pool) or non-targeting control on day 3 of differentiation and harvested on day 7 of differentiation.
ORGANISM(S): Mus musculus 
2026-09-23 | E-MTAB-17577 | biostudies-arrayexpress
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