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Background New approaches are needed to improve prognostic accuracy for treatment response and to explore the complexities of drug effects on human tumours. We developed a strategy of global genomic investigation of sequential tumor biopsies at baseline and 21 days post-treatment, and applied this ...
ORGANISM(S): Homo sapiens 
The purpose of this study was to investigate changes in host gene expression profiles of neonatal infants with sepsis prior to the initiation of and during vancomycin therapy, to identify treatment-responsive genes and signature pathways associated with recovery from neonatal sepsis. The study analy...
ORGANISM(S): Homo sapiens 
We have established a neuroblastoma model resistant in vivo to the topoisomerase I inhibitor irinotecan (CPT-11, Camptothecin-11, CAMPTOSAR®) in order to study resistance to these agents acquired in a therapeutic setting. Common mechanisms of resistance were not involved in this model and we thus ex...
ORGANISM(S): Homo sapiens 
Chytridiomycosis is an emerging infectious disease of amphibians caused by the chytrid Batrachochytrium dendrobatidis (Bd). The disease has been associated with global amphibian declines and is driving the species in the wild to extinction. Using DNA microarray technology we have analysed transcript...
ORGANISM(S): Xenopus tropicalis 
Investigation of whole genome gene expression level changes in African Green Monkeys treated with antimiR-33a/b, compared to the animal treated with vehicle The treatment of the monkeys is further described in Rottiers V, Obad S, McGarrah R, Black JC, Lindholm M, Goody R, Lawrence M, Whetstine JR, G...
ORGANISM(S): Chlorocebus aethiops 
Genomic profiles comparing 23 nevi with a pool of primary cutaneous melanoma
ORGANISM(S): Homo sapiens 
Identification of genomic characteristics in a cohorte of human cutaneous primary melanoma associated with a distant metastasis free survival.
ORGANISM(S): Homo sapiens 
Study by dye-swap of 9 pairs of metastasis/primary melanoma (each from the same patient)
ORGANISM(S): Homo sapiens 
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