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UnknownKL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer's disease.
Not available
S-EPMC8219708 | biostudies-literature
TranscriptomicsDnmt3l-knockout donor cells improve somatic cell nuclear transfer reprogramming efficiency
We found that Dnmt3l-KO donor cells display decreased levels of H3K9me3 and H3K27me3 accumulation, higher level of active histone mark H3K27ac and increased cytoplasmic localization of HDAC1, implicating a permissive epigenetic state beneficial for nuclear reprogramming. To investigate the gene expr...
ORGANISM(S): Mus musculus 
2015-08-01 | E-GEOD-69007 | biostudies-arrayexpress
TranscriptomicsTranscriptome dynamics of developing photoreceptors in 3-D retina cultures recapitulates temporal sequence of human cone and rod differentiation revealing cell surface markers and gene networks
To define molecular mechanisms underlying rod and cone differentiation, we generated H9 human embryonic stem cell line carrying a GFP reporter that is controlled by the promoter of cone-rod homeobox (CRX) gene, the first known marker of post-mitotic photoreceptor precursors. CRXp-GFP reporter in H9 ...
ORGANISM(S): Homo sapiens 
2015-08-03 | E-GEOD-67645 | biostudies-arrayexpress
TranscriptomicsEffect of long-term high CO2 environment on gene expression of Phaeodactylum tricornutum
P. tricornutum (Bacillariophyta, Pennatae, NEPCC640) was obtained from the Algal Center of the Institute of Oceanology of the Chinese Academy of Sciences. The cells were cultured in a modified f/2 medium (Guillard, 1975) at 20 +/- 1C, and illuminated with 120 umol photon m-2 s-1 under a 12:12 light:...
ORGANISM(S): Phaeodactylum tricornutum 
2019-11-07 | E-MTAB-8351 | biostudies-arrayexpress
TranscriptomicsRescue of KRAS suppression in HCT116 colon cancer cell line
Cancer cells that express oncogenic alleles of RAS typically require sustained expression of the mutant allele for survival, but the molecular basis of this oncogene dependency remains incompletely understood. To identify genes that can functionally substitute for oncogenic RAS, we systematically ex...
ORGANISM(S): Homo sapiens 
2014-07-22 | E-GEOD-55942 | biostudies-arrayexpress
UnknownHigh-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations.
Not available
S-EPMC7002524 | biostudies-literature
UnknownTrends in all-cause mortality among people with diagnosed diabetes in high-income settings: a multicountry analysis of aggregate data.
Not available
S-EPMC11318037 | biostudies-literature
UnknownDifferentiation of Prior SARS-CoV-2 Infection and Postacute Sequelae by Standard Clinical Laboratory Measurements in the RECOVER Cohort.
Not available
S-EPMC11408082 | biostudies-literature
UnknownSensory neurons promote immune homeostasis in the lung.
Not available
S-EPMC10811756 | biostudies-literature
UnknownBuparlisib in Patients With Recurrent Glioblastoma Harboring Phosphatidylinositol 3-Kinase Pathway Activation: An Open-Label, Multicenter, Multi-Arm, Phase II Trial.
Not available
S-EPMC6553812 | biostudies-literature
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