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TranscriptomicsAltered interactions between the gut microbiome and colonic mucosa precede polyposis in APCMin/+ mice
Mutation of the adenomatous polyposis coli (APC gene), an early event in the adenoma-carcinoma sequence, is present in 70-80% of sporadic human colorectal adenomas and carcinomas. To test the hypothesis that mutation of the APC gene alters microbial interactions with host intestinal mucosa prior to...
ORGANISM(S): Mus musculus 
2015-08-24 | E-GEOD-67634 | biostudies-arrayexpress
TranscriptomicsA new structural paradigm in copper resistance in a human pathogen
Copper is essential for both innate and adaptive immune function and copper resistance has emerged as an important determinant of virulence of microbial pathogens. In the human pathogen Streptococcus pneumoniae (Spn), cytoplasmic copper resistance is mediated by an operon encoding the copper-respons...
ORGANISM(S): Streptococcus pneumoniae 
2013-05-24 | E-GEOD-39176 | biostudies-arrayexpress
GenomicsDynamic Reorganization of the Cardiomyocyte Transcriptome in Response to TNFM-NM-1-induced Proinflammatory Signaling [ChIP-Seq]
Inflammation is associated with many cardiovascular pathologies, but the underlying mechanisms remain unclear. To explore this in more detail, we characterized the transcriptome of an immortalized adult human ventricular cardiomyocyte cell line (AC16) in response to tumor necrosis factor (TNFa). U...
ORGANISM(S): Homo sapiens 
2014-02-27 | E-GEOD-51169 | biostudies-arrayexpress
UnknownBiallelic MADD variants cause a phenotypic spectrum ranging from developmental delay to a multisystem disorder.
Not available
S-EPMC7447524 | biostudies-literature
UnknownMeta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.
Not available
S-EPMC4922420 | biostudies-literature
UnknownEffect of Transcatheter Aortic Valve Implantation vs Surgical Aortic Valve Replacement on All-Cause Mortality in Patients With Aortic Stenosis: A Randomized Clinical Trial.
Not available
S-EPMC9115619 | biostudies-literature
UnknownRapid and sustained B-cell depletion with subcutaneous ofatumumab in relapsing multiple sclerosis: APLIOS, a randomized phase-2 study.
Not available
S-EPMC9024029 | biostudies-literature
UnknownNew-onset atrial fibrillation and chronic coronary syndrome in the CLARIFY registry.
Not available
S-EPMC10834159 | biostudies-literature
UnknownEffect of community-based voluntary counselling and testing on HIV incidence and social and behavioural outcomes (NIMH Project Accept; HPTN 043): a cluster-randomised trial.
Not available
S-EPMC4131207 | biostudies-literature
UnknownAge-Related Differences in Socio-demographic and Behavioral Determinants of HIV Testing and Counseling in HPTN 043/NIMH Project Accept.
Not available
S-EPMC5718984 | biostudies-literature
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