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ProteomicsAutoinhibition of Trio guanine nucleotide exchange factor activity for Rac1 by its spectrin repeats is disrupted by neurodevelopmental disorder-related genetic variants
Crosslinking MS of SR6-GEF1 construct of Human Trio. BS3 crosslinking of wild-type and three point mutants implicated in neurodevelopmental disorders (E883D, R1078Q, D1368V). Data acquired using FAIMS ion mobility source with each sample acquired at 4 different CVs (-40, -50, -60, -70V).
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-06-08 | MSV000089621 | MassIVE
UnknownInfluence of water deficit on the molecular responses of Pinus contorta × Pinus banksiana mature trees to infection by the mountain pine beetle fungal associate, Grosmannia clavigera.
Not available
S-EPMC4277265 | biostudies-literature
UnknownRNA sequencing reveals molecular mechanisms of endometriosis lesion development in mice.
Not available
S-EPMC11524442 | biostudies-literature
TranscriptomicsMouse Exons
Exon tiling array encompassing 837,251 probes across the mouse genome. 12 tissue pools. Composition of the 12 mRNA pools analyzed (mRNA per array hybridization): 1- Heart (2 microgram), Skeletal muscle (2 microgram) 2- Liver (2 microgram) 3- Whole brain (1.5 microgram), Cerebellum (0.48 micr...
ORGANISM(S): Mus musculus 
2010-07-01 | E-GEOD-3047 | biostudies-arrayexpress
UnknownDeep active learning for suggestive segmentation of biomedical image stacks via optimisation of Dice scores and traced boundary length.
Not available
S-EPMC11605667 | biostudies-literature
ProteomicsDepletion of Mitochondrial Methionine Adenosyltransferase α1 Triggers Mitochondrial Dysfunction in Alcohol-Associated Liver Disease
Mitochondrial MATα1 is selectively depleted in alcohol-associated liver disease through a mechanism that involves the isomerase PIN1 and the kinase CK2. Alcohol activates CK2, which phosphorylates MATα1 at Ser114 facilitating interaction with PIN1, thereby inhibiting its mitochondrial localization. ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-02-17 | PXD030383 | Pride
Liver Matα1 Mitochondria Alcohol 
UnknownA 127 kb truncating deletion of PGRMC1 is a novel cause of X-linked isolated paediatric cataract.
Not available
S-EPMC8385038 | biostudies-literature
UnknownIron is a ligand of SecA-like metal-binding domains in vivo.
Not available
S-EPMC7247292 | biostudies-literature
UnknownAnti-fibrillarin antibody in African American patients with systemic sclerosis: immunogenetics, clinical features, and survival analysis.
Not available
S-EPMC3149738 | biostudies-literature
ProteomicsThe B Cell Repertoire in Multiple Sclerosis Reveals Molecular Mimicry between EBNA1 and GlialCAM
This data set contains the mass spectrometry raw files for the paper The B Cell Repertoire in Multiple Sclerosis Reveals Molecular Mimicry between EBNA1 and GlialCAM. In multiple sclerosis (MS) intrathecal B lymphocytes are directly involved in inflammation and secrete oligoclonal immunoglobulin. Ho...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-02-11 | MSV000086842 | MassIVE
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