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TranscriptomicsChemical potentiator of copper-accumulation and -toxicity: Probing iron- regulons of Saccharomyces cerevisiae
RNA-seq was used to assess mRNA transcript abundance in wild type and fra2M-NM-^T S. cerevisiae (BY4741) cells treated with 2-(6-benzyl-2-pyridyl)quinazoline (BPQ) and CuSO4. BPQ potentiates copper toxicity and in yeast, in common with other organisms, a major cause of copper toxicity is damage of i...
ORGANISM(S): Saccharomyces cerevisiae 
2014-06-04 | E-GEOD-54045 | biostudies-arrayexpress
GenomicUse of WGS for Diagnosis and Discovery in the Cancer Genetics Clinic

Despite the potential of whole-genome sequencing (WGS) to improve patient diagnosis and care, the empirical value of WGS in the cancer genetics clinic is unknown. We performed WGS on members of two cohorts of cancer genetics patients: those with BRCA1/2 mutations (n = 176) and those without (n = ...

phs000942 | dbGaP
TranscriptomicsEGFR Mutation Promotes Glioblastoma Through Epigenome and Transcription Factor Network Remodeling
Epidermal Growth Factor Receptor (EGFR) gene amplification and mutations are the most common oncogenic events in Glioblastoma (GBM), but the mechanisms by which they promote aggressive tumor growth are not well understood. Here, through integrated epigenome and transcriptome analyses of cell lines, ...
ORGANISM(S): Homo sapiens 
2015-09-14 | E-GEOD-72468 | biostudies-arrayexpress
UnknownEnhancing cognitive performance prediction by white matter hyperintensity connectivity assessment.
Not available
S-EPMC11629703 | biostudies-literature
UnknownAI is a viable alternative to high throughput screening: a 318-target study.
Not available
S-EPMC10987645 | biostudies-literature
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