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GenomicsGlutamine methylation on Histone H2A is an RNA Polymerase I dedicated modification
Nucleosomes are decorated with numerous post-translational modifications capable of influencing many DNA processes. Here, we describe a new class of modification, methylation of glutamine, occurring on yeast histone H2A at position 105 (Q105) and human H2A at Q104. We identify Nop1 as the methyltran...
ORGANISM(S): Saccharomyces cerevisiae 
2014-01-21 | E-MTAB-1447 | biostudies-arrayexpress
GenomicsDriver mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in Acute Myeloid Leukemia
Recent evidence suggests that inhibition of BET epigenetic readers may have clinical utility in hematological malignancies. We demonstrate the efficacy of the BET inhibitor I-BET151 across a variety of AML subtypes, and demonstrate that a common core transcriptional program, which is HOX gene-indepe...
ORGANISM(S): Homo sapiens 
2014-12-12 | E-MTAB-1443 | biostudies-arrayexpress
TranscriptomicsRNA-seq comparison of immortalised myoblasts from dystrophic and WT mice
Pathophysiology of Duchenne Muscular Dystrophy (DMD) is still elusive. Although progressive damage to muscle fibres is a cause of muscle deterioration leading to premature death, there is a growing body of evidence indicating that the triggering effects of DMD mutation are present at the very early ...
ORGANISM(S): Mus musculus 
2019-10-02 | E-MTAB-7287 | biostudies-arrayexpress
TranscriptomicsLoss of full-length dystrophin expression causes major cell-autonomous abnormalities in proliferating myoblasts
Duchenne muscular dystrophy (DMD) is a severely debilitating and incurable neuromuscular disease. Its conspicuous feature is the absence of dystrophin in myofibers and therefore most therapeutic approaches focus on some form of its re-expression there. However, increasing body of evidence points at ...
ORGANISM(S): Mus musculus 
2022-09-14 | E-MTAB-10322 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression analysis of H4T80A mutants vs WT H4 in Saccharomyces cerevisiae
Global RNA-seq gene expression analysis of H4T80A mutants vs WT H4 in Saccharomyces cerevisiae.
ORGANISM(S): Saccharomyces cerevisiae 
2018-09-05 | E-MTAB-7090 | biostudies-arrayexpress
TranscriptomicsSubtle effects of radiation on embryo development of the 3-spined stickleback
Following serious accidents at the Chernobyl and Fukushima nuclear power plants in 1986 and 2011 respectively, local flora and fauna have been chronically exposed to environmental radiation for many years . However, little is known about the environmental effects of low doses of radiation on aquatic...
ORGANISM(S): Gasterosteus aculeatus 
2020-02-04 | E-MTAB-7872 | biostudies-arrayexpress
TranscriptomicsNAT10 inhibition improves cellular phenotypes of Hutchinson-Gilford progeria syndrome by restoring the Transportin-1 pathway
In this experiment, we aim to examine the role of NAT10 inhibition in Hutchinson-Gilford progeria syndrome (HGPS), a rare but devastating premature ageing syndrome caused by a mutation in the LMNA gene. NAT10 inhibition improves HGPS cellular phenotypes by releasing Transportin-1 (TNPO1) from the cy...
ORGANISM(S): Homo sapiens 
2018-06-25 | E-MTAB-6651 | biostudies-arrayexpress
TranscriptomicsInhibition of bromodomain and extra-terminal (BET) recruitment to chromatin as an effective treatment for mixed lineage leukaemia (MLL)-fusion leukaemia
Gene expression changes in MLL leukaemia following I-BET151 treatment. Note: Additional archives available (E-MTAB-774.additional.1.zip and E-MTAB-774.additional.2.zip) containing individual raw files. Select 'Browse all available files' to view.
ORGANISM(S): Homo sapiens 
2011-09-30 | E-MTAB-774 | biostudies-arrayexpress
TranscriptomicsRNA-seq comparison of whole muscle between WT mice, dystrophic mice, and P2rx7-null dystrophic mice
Duchenne muscular dystrophy (DMD) is a debilitating and typically fatal X-linked progressive neuromuscular disorder that results in progressive muscle degeneration aggravated by sterile inflammation. The P2RX7 purinoceptor is an extracellular ATP-gated ion channel expressed in immune cells, and has ...
ORGANISM(S): Mus musculus 
2019-09-26 | E-MTAB-7698 | biostudies-arrayexpress
GenomicsSox2 is present in RNA binding complexes and interacts with snRNA 7SK in mouse embryonic stem cells
Sox2 is a master transcriptional regulator of embryonic development and has been found to interact with RNA binding proteins such as the non-coding RNA 7SK. 7SK has been shown to regulate transcription at regulatory regions, which could suggest a functional interaction with Sox2 for chromatin recrui...
ORGANISM(S): Mus musculus 
2019-05-07 | E-MTAB-7570 | biostudies-arrayexpress
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