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GenomicsStationary phase gene regulation by the group A Streptococcus protein RocA
Stationary phase gene regulation by the group A Streptococcus protein RocA
PRJNA543030 | ENA
TranscriptomicsRocaglamide A converts RNA helicase eIF4A into a sequence-specific translational repressor
Rocaglamide A (RocA) typifies a novel class of protein synthesis inhibitors that selectively kill aneuploid tumor cells and repress translation of specific mRNAs. RocA targets eukaryotic initiation factor 4A (eIF4A), the prototypical DEAD-box RNA helicase, and its mRNA selectivity is proposed to ref...
ORGANISM(S): synthetic construct 
2016-06-15 | E-GEOD-70211 | biostudies-arrayexpress
TranscriptomicsRocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor
Rocaglamide A (RocA) typifies a class of protein synthesis inhibitors that selectively kill aneuploid tumor cells and repress translation of specific mRNAs. RocA targets eukaryotic initiation factor 4A (eIF4A), an ATP-dependent DEAD-box RNA helicase; its mRNA selectivity is proposed to reflect highl...
ORGANISM(S): synthetic construct 
2016-06-15 | E-GEOD-79392 | biostudies-arrayexpress
GenomicsStationary phase gene regulation in M1 GAS by the group A Streptococcus protein RocA
Stationary phase gene regulation in M1 GAS by the group A Streptococcus protein RocA
PRJNA543021 | ENA
TranscriptomicsStationary phase gene regulation by the group A Streptococcus protein RocA
We used RNA-Seq to assess how RocA regulates gene expression in stationary phase GAS cultures
ORGANISM(S): Streptococcus pyogenes 
2019-11-22 | GSE131239 | GEO
TranscriptomicsPolymorphisms in RocA contribute to the molecular pathogenesis of serotype M28 group A streptococcus
RNA-seq experiments of serotype M28 group A streptococcus strains with mutations in rocA at two time points
ORGANISM(S): Streptococcus pyogenes 
2019-06-25 | GSE133203 | GEO
TranscriptomicsRocA has serotype-specific gene regulatory and pathogenesis activity in serotype M28 group A streptococcus
RNA-seq experiments of a wild-type and isogenic rocA deletion mutant serotype M28 group A streptococcus strain at two time points
ORGANISM(S): Streptococcus pyogenes 
2018-08-27 | GSE118609 | GEO
OtherTernary protein•drug•RNA interface explains RocA sequence selectivity and Aglaia resistance
A novel class of translation inhibitors isolated from Aglaia plants, exemplified by Rocaglamide A (RocA), shows promise as an anti-cancer therapy. RocA converts its molecular target, translation initiation factor 4A (eIF4A), a DEAD-box protein, into a purine-selective RNA-binding protein that repres...
ORGANISM(S): Homo sapiens 
2018-12-30 | GSE102720 | GEO
UnknownIdentification of rocA, a positive regulator of covR expression in the group A streptococcus.
Not available
S-EPMC154078 | biostudies-literature
TranscriptomicsRocA regulates gene expression in serotype M1 group A Strep (GAS, aka S. pyogenes)
We used RNA-Seq to assess whether the rocA gene regulates gene expression in M1 GAS
ORGANISM(S): Streptococcus pyogenes 
2017-08-08 | GSE97325 | GEO
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