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Bone marrow (BM) niches provide an optimal substrate for multiple myeloma (MM) cell lodgement and growth. Nevertheless, little is known about the putative mechanisms by which the BM microenvironment can lead to initiation or progression of oncogenesis in this disease. We have demonstrated that BM m...
ORGANISM(S): Homo sapiens 
C1013G/CXCR4 variant has been inserted into BCWM.1 cells, and gene expression profile has been performed on the mutated cells and on the parental cells. Affimetrix Human Genome U133_Plus2.0 array We used microarrays to dissect the possible changes occurring at mRNA level in mutated cells versus the ...
ORGANISM(S): Homo sapiens 
Mice have been treated with olaptesed pegol (NOX-A12). Whole BM cells have been harvested, RNA isolated, and gene expression profiling was performed on cDNA using Mouse Genome 430 2.0 array. Untreated mice have been used as control. Mice have been treated with NOX-A12. Whole BM cells have been harve...
ORGANISM(S): Mus musculus 
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