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TranscriptomicsAfter demyelination in the adult CNS, oligodendrocyte precursor cells revert to an immature mRNA profile and express immune cues favoring their migration
In multiple sclerosis (MS) and experimental models of demyelination, myelin repair is mostly achieved by oligodendrocyte precursor cells (OPCs). To gain insight into the biological specificity of these adult precursors, in the perspective to better understand why remyelination often fails in MS, we ...
ORGANISM(S): Mus musculus 
2014-11-06 | E-GEOD-48872 | biostudies-arrayexpress
TranscriptomicsZfx controls BCR-induced proliferation and survival of B lymphocytes
The development, homeostasis and function of B lymphocytes involve multiple rounds of B cell receptor (BCR)-controlled proliferation and prolonged maintenance. We analyzed the role of transcription factor Zfx, a recently identified regulator of stem cell maintenance, in B cell development and homeos...
ORGANISM(S): Mus musculus 
2009-04-16 | E-GEOD-13547 | biostudies-arrayexpress
GenomicsGenome-wide mapping of meiotic double-strand breaks by sequencing Spo11 oligos.
The nonrandom distribution of meiotic recombination shapes patterns of inheritance and genome evolution, but chromosomal features governing this distribution are poorly understood. Formation of the DNA double-strand breaks (DSBs) that initiate recombination results in accumulation of Spo11 protei...
ORGANISM(S): Saccharomyces cerevisiae 
2011-03-07 | E-GEOD-26449 | biostudies-arrayexpress
TranscriptomicsA database of circadian and diel rhythmic gene expression in the yellow fever mosquito Aedes aegypti
Investigation of whole genome gene expression level changes during a 44 hour time period in Aedes aegypti observed under light/dark and constant dark conditions. This is a 12-plex high defination NimbleGen array design. The Higgs White Eye (Wh) strain of Aedes aegypti was investigated for rhythmic e...
ORGANISM(S): Aedes aegypti 
2014-08-19 | E-GEOD-60496 | biostudies-arrayexpress
TranscriptomicsWhiA and WhiB of Streptomyces venezuelae depend on each other for binding DNA
WhiB regulon, as determined by ChIP-Seq turned out to be identical to the WhiA regulon leading to the speculation that the two proteins might be required to work together to bind DNA. In this experiment WhiA ChIP-Seq was done in a whiB deletion background and, WhiB ChIP-Seq was done in a whiA deleti...
ORGANISM(S): Streptomyces venezuelae 
2021-07-01 | E-MTAB-10673 | biostudies-arrayexpress
TranscriptomicsMyeloid malignancies with chromosome 5q deletions acquire a dependency on an intrachromosomal NF-M-NM-:B gene network
Chromosome 5q deletions (del(5q)) are common in high-risk (HR) Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML); however, the gene regulatory networks that sustain these aggressive diseases are unknown. Reduced miR-146a expression in del(5q) HR-MDS/AML and miR-146a-/- hematopoietic st...
ORGANISM(S): Homo sapiens 
2014-08-23 | E-GEOD-60649 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Hepatitis C patients - responders and non-responders to antiviral therapies peg interferon and ribavirin against hepatitis C
Time series of gene expression arrays before and during treatment of Hepatitis C; days 0, 1, 2, 7, 14 and 28 for 69 participants (IDs 1 through 69 are used). Treating chronic hepatitis C using peginterferon alpha and ribavirin leads to sustained clearance of virus and clinical improvement in approxi...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-7123 | biostudies-arrayexpress
TranscriptomicsMapping of cohesion factor association sites in S. cerevisiae - Meiosis I chromosome segregation is established through regulation of microtubule-kinetochore interactions.
During meiosis, a single round of DNA replication is followed by two consecutive rounds of nuclear divisions called meiosis I and meiosis II. In meiosis I, homologous chromosomes segregate, while sister chromatids remain together. Determining how this unusual chromosome segregation behavior is estab...
ORGANISM(S): Saccharomyces cerevisiae 
2012-10-05 | E-GEOD-41339 | biostudies-arrayexpress
TranscriptomicsVallier 3day endoderm
Transcriptional profiling of H9 human embryonic stem cells differentiated towards early endoderm over 72 hours in chemically defined media.
ORGANISM(S): Homo sapiens 
2011-01-26 | E-MTAB-467 | biostudies-arrayexpress
TranscriptomicsChIP-Seq to determine the binding sites of the transcription factor WhiB in the genome of Streptomyces venezuelae
WhiB is the founding member of a family of proteins (the WhiB-like [Wbl] family) that carry a [4Fe-4S] iron-sulfur cluster. It is essential for the process of developmentally controlled cell division leading to sporulation in Streptomyces species. This ChIP-Sea was carried out to determine unambiguo...
ORGANISM(S): Streptomyces venezuelae 
2021-06-25 | E-MTAB-10648 | biostudies-arrayexpress
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