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GenomicsDynamic hydroxymethylation of DNA marks differentiation-driven enhancers
This SuperSeries is composed of the following subset Series: GSE27334: Whole-genome gene expression level changes in P19.6 mouse embryonal carcinoma cells compared to P19.6 cells treated for 48 hours with all-trans retinoic acid GSE33067: Whole-genome mapping of MEIS1, TET1, H3K4me2 and H3K27ac in P...
ORGANISM(S): Mus musculus 
2012-06-03 | E-GEOD-27436 | biostudies-arrayexpress
GenomicsWhole-genome mapping of MEIS1, TET1, H3K4me2 and H3K27ac in P19.6 mouse embryonal carcinoma cells and P19.6 cells treated for 48 hours with all-trans retinoic acid
Enhancers are developmentally-controlled transcriptional regulatory regions whose activities are modulated through histone modifications or histone variant deposition. Here, we show by genome-wide mapping that the newly discovered DNA modification 5-hydroxymethylcytosine (5hmC) is dynamically associ...
ORGANISM(S): Mus musculus 
2012-06-04 | E-GEOD-33067 | biostudies-arrayexpress
TranscriptomicsPhenotypic differences in dopaminergic circuitries of mouse strains are associated with extensive regulatory variation in the midbrain
The nigrostriatal circuitry in the substantia nigra (SN) exerts control over the motor system and the loss of dopaminergic neurons (DAns) in the SN is the primary cause of Parkinson’s disease (PD). We have performed RNA-seq, ChIP-seq, and ATAC-seq analysis of the ventral midbrains of three widely us...
ORGANISM(S): Mus musculus 
2019-10-07 | E-MTAB-8333 | biostudies-arrayexpress
TranscriptomicsCell-specific and spatio-temporal controls of the estrogen-responsive trefoil factor (TFF) locus activity
Cell-specific transcriptional regulations exerted by the estrogen (E2) receptor alpha (ER) heavily rely upon timely and spatially coordinated processes. We engaged a comparative analysis of such dynamic molecular events at the TFF locus harbouring a cluster of genes co-regulated by E2, in two distin...
ORGANISM(S): Homo sapiens 
2014-05-06 | E-GEOD-32132 | biostudies-arrayexpress
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