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TranscriptomicsNon-genotoxic Hepatocarcinogens
There is no accurate and well-validated short-term test for non-genotoxic carcinogens, necessitating an expensive two year rodent bioassay before a risk assessment can begin. We have developed a short-term in vivo rat assay that predicts whether non-genotoxic chemicals are likely to induce hepatic t...
ORGANISM(S): Rattus norvegicus 
2007-06-22 | E-GEOD-8251 | biostudies-arrayexpress
TranscriptomicsLiver Pharmacology and Xenobiotic Response Repertoire
A definition of RNA expression changes that correlate with liver response programs and an understanding of the similarities and differences in responses to different classes of chemicals would aid in new chemical or drug characterization and add to our understanding of liver biology. We have used a ...
ORGANISM(S): Rattus norvegicus 
2008-03-28 | E-GEOD-8858 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of liver from Dahl salt sensitive (SS) rats and SS9BN consomic rats during hypoxia treatment
Examination of gene expression associated with hypoxia treatment of parental salt sensitive (SS) and consomic Brown Norway (SS9BN) rat strain. SS9BN rats are derived from introgression of chromosome 9 from BN rats into the SS genetic background.
ORGANISM(S): Rattus norvegicus 
2006-09-15 | E-TIGR-126 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of lung from Dahl salt sensitive (SS) rats and SS11BN consomic rats during hypoxia treatment
Examination of gene expression changes during hypoxia of the Dahl salt sensative (SS) rat and SS11BN consomic rat. SS11BN rats are derived from introgression of chromosome 11 from Brown Norway (BN) rat into the SS genetic background.
ORGANISM(S): Rattus norvegicus 
2006-09-15 | E-TIGR-116 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of lung from Dahl salt sensitive (SS) rats and SS4BN consomic rats during hypoxia treatment
Examination of gene expression changes during hypoxia of the Dahl salt sensative (SS) rat and SS4BN consomic rat. SS4BN rats are derived from introgression of chromosome 4 from Brown Norway (BN) rat into the genetic background.
ORGANISM(S): Rattus norvegicus 
2006-09-15 | E-TIGR-118 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mice fed salt water to induce hypertension to assess strain and sex specific differences
Some mice were fed salt water to induce hypertension and some fed normal water to see how hypertension is different among different strains, tissues, and sexes
ORGANISM(S): Mus musculus 
2005-01-27 | E-TIGR-107 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of lung from Dahl salt sensitive (SS) rats and SS9BN consomic rats during hypoxia treatment
Examination of gene expression associated with hypoxia treatment of parental salt sensitive (SS) and consomic Brown Norway (SS9BN) rat strain. SS9BN rats are derived from introgression of chromosome 9 from BN rats into the SS genetic background.
ORGANISM(S): Rattus norvegicus 
2006-09-15 | E-TIGR-127 | biostudies-arrayexpress
TranscriptomicsNuclear Localization of Hog1 MAPK is Not Necessary for Resistance to Hyperosmotic Stress
In budding yeast, this signaling pathway— the high-osmolarity glycerol (HOG) response —culminates in dual phosphorylation and nuclear translocation of the MAPK, Hog1 (ortholog of mammalian p38/SAPK). Induction of at least 50 genes requires nuclear Hog1, implying that transcriptional up-regulation...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-01 | E-GEOD-8703 | biostudies-arrayexpress
GenomicsHoxc9 ChIP-seq in differentiating motor neurons
The expression of v5-tagged Hoxc9 is induced and ChIP-seq is used to profile genome-wide occupancy in differentiating motor neurons The differentiation of ventral motor neurons is induced by treating embryonic stem cell cultures with retinoic acid and hedgehog signaling. Here, ChIP-seq is used to pr...
ORGANISM(S): Mus musculus 
2010-09-08 | E-GEOD-21812 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of heart during hypoxia of the Fawn Hooded Hypertensive (FHH) rat and FHH12BN consomic rat
Examination of gene expression changes during hypoxia of the Fawn Hooded Hypertensive (FHH) rat and FHH12BN consomic rat. FHH12BN rats are derived from introgression of chromosome 12 and from the Brown Norway (BN) rat into the FHH genetic background.
ORGANISM(S): Rattus norvegicus 
2006-09-15 | E-TIGR-111 | biostudies-arrayexpress
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