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ProteomicsThe GTPase Rab39a matures phagosomes into MHC-I antigen-presenting compartments.
This is the mass spec data from phagosomes of Rab39a deficient or Rab39a induced dendritic cell lines. For reference, see: Cruz FM, Colbert JD, Rock KL: The GTPase Rab39a matures phagosomes into MHC-I antigen-presenting compartments. . EMBO J (in press). Silac: Rab39a KO (Light), Rab39a induced (...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-11-21 | MSV000084611 | MassIVE
TranscriptomicsA Primate lncRNA Mediates Notch Signaling During Neuronal Development by Sequestering miRNA
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-06-23 | E-GEOD-74210 | biostudies-arrayexpress
TranscriptomicsA Primate lncRNA Mediates Notch Signaling During Neuronal Development by Sequestering miRNA [single cell sequencing analysis]
Long non-coding RNAs (lncRNAs) are a diverse category of transcripts with poor conservation and have expanded greatly in primates, particularly in their brain. We identified a lncRNA, which has acquired 16 microRNA response elements (MREs) for miR-143-3p in the Catarrhini branch of primates. This ln...
ORGANISM(S): Homo sapiens 
2016-06-23 | E-GEOD-74207 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of human neural progenitor cells and neurons with DISC1 interruption
Purpose: Genetic and clinical association studies have identified disrupted-in-schizophrenia 1 (DISC1) as a candidate risk gene for major mental illness. DISC1 is interrupted by a balanced chr(1;11) translocation in a Scottish family, in which the translocation predisposes to psychiatric disorders. ...
ORGANISM(S): Homo sapiens 
2015-09-14 | E-GEOD-71289 | biostudies-arrayexpress
TranscriptomicsRole of SPI-1 Secreted Effectors, SipA, SopABDE2, in Acute Bovine Response to Salmonella enterica Serovar Typhimurium
Salmonella enterica Serovar Typhimurium (S. Typhimurium) causes enterocolitis in humans and calves characterized by diarrhea and polymorphonuclear cell (PMN) influx to the intestinal mucosa. The Salmonella Type III Secretion System encoded at Pathogenicity Island I (SPI-1) translocates the Salmonel...
ORGANISM(S): Bos taurus 
2012-01-10 | E-GEOD-13847 | biostudies-arrayexpress
TranscriptomicsHeme-induced inhibition of Bach1derepresses Spic.
Splenic red pulp macrophages (RPM) degrade senescent erythrocytes and recycle heme-associated iron. The transcription factor Spic is selectively expressed by RPM and is required for their development, but the physiologic stimulus inducing Spic is unknown. Here, we report that Spic also regulated the...
ORGANISM(S): Mus musculus 
2014-03-14 | E-GEOD-53796 | biostudies-arrayexpress
TranscriptomicsHeme regulates the development of iron-recycling macrophages from monocytes (heme-treated BMM)
Splenic red pulp macrophages (RPM) degrade senescent erythrocytes and recycle heme-associated iron. The transcription factor Spic is selectively expressed by RPM and is required for their development, but the physiologic stimulus inducing Spic is unknown. Here, we report that Spic also regulated the...
ORGANISM(S): Mus musculus 
2014-03-14 | E-GEOD-46983 | biostudies-arrayexpress
TranscriptomicsBovine Peyer's Patch Infected with Mycobacterium avium ssp. paratuberculosis and Mycobacterium avium ssp. avium
Mycobacterium avium subspecies paratuberculosis (MAP) infection is established following the ingestion of bacteria, their penetration of the intestinal mucosa and subsequent events of the host-parasite interaction. These bacteria invade M cells, macrophages and are capable of resisting host defenses...
ORGANISM(S): Bos taurus 
2012-10-03 | E-GEOD-13888 | biostudies-arrayexpress
GenomicsERM-NM-1 and PolII ChIP seq from Mouse Uterus
To advance understanding of mechanisms leading to biological and transcriptional endpoints related to estrogen action in the mouse uterus, we have mapped ERM-NM-1 and RNA polymerase II binding sites using chromatin immunoprecipitation (ChIP) followed by sequencing of enriched chromatin fragments (Ch...
ORGANISM(S): Mus musculus 
2012-04-08 | E-GEOD-36455 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of the Arabidopsis root quiescent center
The Arabidopsis quiescent center (QC) is a small group of cells with low mitotic activity located at the center of the root stem cell niche. Its transcriptional profile was previously analyzed using two repeats of cells FACS isolated using the AGL42 marker. To get more power in analyzing QC transcri...
ORGANISM(S): Arabidopsis thaliana 
2014-12-17 | E-GEOD-64253 | biostudies-arrayexpress
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