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TranscriptomicsHierarchical synergy of Pten, p53 and Rb pathways in high-grade astrocytoma induced in adult brain
Mutations in the PTEN, TP53 and RB1 pathways are obligate events in the pathogenesis of human glioblastomas, the highest grade of astrocytoma. To investigate synergy between these tumor suppressors in mice, we induced various combinations of compound deletions conditionally in astrocytes and neural ...
ORGANISM(S): Mus musculus 
2011-03-23 | E-GEOD-22927 | biostudies-arrayexpress
TranscriptomicsTranscription factor Rbf1 is the master regulator for b-mating type controlled pathogenic development in Ustilago maydis
This SuperSeries is composed of the following subset Series: GSE18750: Controlled expression of compatible and incompatible combinations of Ustilago maydis b-mating type locus genes bE and bW GSE18754: Effect of rbf1 deletion during controlled expression of of Ustilago maydis b-mating type locus gen...
ORGANISM(S): Ustilago maydis 
2010-06-01 | E-GEOD-18881 | biostudies-arrayexpress
TranscriptomicsEffect of rbf1 deletion during controlled expression of Ustilago maydis b-mating type locus genes bE1 and bW2
In the phytopathogenic Basidiomcete Ustilago maydis, sexual and pathogenic development are tightly connected and controlled via the b-mating type locus. The b-mating type locus encodes two homeodomain transcription factors, bE and bW, which form an active heterodimeric complex when they are derived ...
ORGANISM(S): Ustilago maydis 
2010-06-01 | E-GEOD-18754 | biostudies-arrayexpress
TranscriptomicsControlled expression of compatible and incompatible combinations of Ustilago maydis b-mating type locus genes bE and bW
In the phytopathogenic Basidiomcete Ustilago maydis, sexual and pathogenic development are tightly connected and controlled via the b-mating type locus. The b-mating type locus encodes two homeodomain transcription factors, bE and bW, which form an active heterodimeric complex when they are derived ...
ORGANISM(S): Ustilago maydis 
2010-06-01 | E-GEOD-18750 | biostudies-arrayexpress
TranscriptomicsDeregulation of microRNAs by HIV-1 Vpr protein leads to the development of neurocognitive disorders.
Studies have shown that HIV-infected patients develop neurocognitive disorders characterized by neuronal dysfunction. The lack of productive infection of neurons by HIV suggests that viral and cellular proteins, with neurotoxic activities, released from HIV-1-infected target cells can cause this neu...
ORGANISM(S): Homo sapiens 
2013-02-12 | E-GEOD-44266 | biostudies-arrayexpress
UnknownDiagnostic usefulness and prognostic impact of CD200 expression in lymphoid malignancies and plasma cell myeloma.
Not available
S-EPMC3632327 | biostudies-literature
TranscriptomicsGenome-wide Analyses of Diffuse Intrinsic Pontine Gliomas
Purpose: More than 90% of children with diffuse intrinsic pontine glioma (DIPG) die within 2 years of diagnosis. There is a dire need to identify therapeutic targets, however lack of patient material for research has limited progress. We evaluated a large cohort of diffuse intrinsic pontine gliomas ...
ORGANISM(S): Homo sapiens 
2011-09-20 | E-GEOD-26576 | biostudies-arrayexpress
UnknownAssessment of Patient-Reported Outcome Measures for Maternal Postpartum Depression Using the Consensus-Based Standards for the Selection of Health Measurement Instruments Guideline: A Systematic Review.
Not available
S-EPMC9233232 | biostudies-literature
GenomicsThe DREAM complex promotes gene body deposition of H2A.Z for target repression
As part of a study of the function of the C. elegans DREAM complex, here we have used ChIP-seq to analyze the patterns of histone variant HTZ-1/H2A.Z and various histone modifications in lin-35(n745) mutants. In addition, we have used RNA-seq to analyze gene expression in lin-35 and htz-1 mutants as...
ORGANISM(S): Caenorhabditis elegans 
2015-04-02 | E-GEOD-62833 | biostudies-arrayexpress
TranscriptomicsTranscriptional signature of C/EBPBeta in Hep3B cells: Involvement of the LAP and LIP isoforms in hepatocarcinogenesis
C/EBPβ plays a major role in numerous biological processes but unfortunately its precise role is not still clear and conflicting studies showed that this transcription factor could have contradictory functions. These latter arise from the complexity of mechanisms regulating C/EBPβ activity. Indeed, ...
ORGANISM(S): Homo sapiens 
2011-01-16 | E-GEOD-12410 | biostudies-arrayexpress
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