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TranscriptomicsTranscriptome analyses during disease progression
Transcriptome was assessed in the transitions from the normal thymus (with regular progenitor turnover), to a thymus devoid of extrinsic progenitor competition for 10 weeks, to fully malignant T cell acute lymphoblastic leukemia (T-ALL). Comparison of global gene expression between normal thymus, to...
ORGANISM(S): Mus musculus 
2014-05-16 | E-GEOD-56417 | biostudies-arrayexpress
TranscriptomicsCell competition regulates thymocyte turnover
Wild type thymi were transplanted into a competitive (wild type hosts), or non-competitive (Rag2-/-γc-/-KitW/Wv hosts) environment. Triple negative 2 and 3 (TN2/3) stages were sorted 14 days afetr transplantation and separated for cells of host or donor origin. Global gene expression data for TN2/3 ...
ORGANISM(S): Mus musculus 
2014-05-16 | E-GEOD-56418 | biostudies-arrayexpress
TranscriptomicsIntrathymic origins of T-ALL
Leukemia cells are considered developmentally 'frozen', and their phenotype is thought to reflect their stage of origin. To gain insights into the cell population from which T-ALL arises, we compared by global gene expression profiling T-ALL samples (n = 10) to different stages of T cell development...
ORGANISM(S): Mus musculus 
2014-05-16 | E-GEOD-56416 | biostudies-arrayexpress
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