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GenomicsGlobal methylation alterations in Dnmt3aKO derived malignancies
To test the long-term effects of lack of Dnmt3a on mouse HSCs, we established a cohort of lethally irradiated mice transplanted with Dnmt3a-KO or WT HSC control cells. Dnmt3a deletion in purified HSCs transplanted alone leads to an array of hematologic disorders that models the spectrum of disorders...
ORGANISM(S): Mus musculus 
2014-12-08 | E-GEOD-60264 | biostudies-arrayexpress
GenomicsLarge conserved domains of low DNA methylation maintained by 5-hydroxymethycytosine and Dnmt3a (CMS bisulfite-seq)
Gains and losses in DNA methylation are prominent genomic features of all mammalian cell types. To gain insight into mechanisms that could promote shifts in DNA 5-hydroxymethylation (5hmc) patterns and thus contribute to cell fate, including malignant transformation, we performed genome-wide mappin...
ORGANISM(S): Mus musculus 
2014-01-22 | E-GEOD-53742 | biostudies-arrayexpress
UnknownStudy protocol: COmparison of the effect of treatment with Nonsteroidal anti-inflammatory drugs added to anti-tumour necrosis factor a therapy versus anti-tumour necrosis factor a therapy alone on progression of StrUctural damage in the spine over two years in patients with ankyLosing spondylitis (CONSUL) - an open-label randomized controlled multicenter trial.
Not available
S-EPMC5623356 | biostudies-literature
TranscriptomicsGene expression in human glioblastoma specimens
We assessed global gene expression changes in 32 human glioblastoma specimens Human mRNA profiles of 32 glioblastoma specimens, were obtained by sequencing on Illumina HiSeq 3000
ORGANISM(S): Homo sapiens 
2016-03-17 | E-GEOD-77530 | biostudies-arrayexpress
UnknownImaging Mass Cytometry-Based Immune Profiling of Human Peyer's Patches in Patients with Crohn's Disease.
Not available
S-EPMC12501404 | biostudies-literature
UnknownExploring complement biomarkers in suspected axial spondyloarthritis.
Not available
S-EPMC11328660 | biostudies-literature
UnknownAnalysis of Circulating Food Antigen-Specific T-Cells in Celiac Disease and Inflammatory Bowel Disease.
Not available
S-EPMC10179603 | biostudies-literature
GenomicsLarge conserved domains of low DNA methylation maintained by 5-hydroxymethycytosine and Dnmt3a [Bisulfite-Seq]
Gains and losses in DNA methylation are prominent genomic features of all mammalian cell types. To gain insight into mechanisms that could promote shifts in DNA methylation patterns and thus contribute to cell fate, including malignant transformation, we performed genome-wide mapping of 5-methylcyt...
ORGANISM(S): Mus musculus 
2013-11-17 | E-GEOD-49714 | biostudies-arrayexpress
GenomicsLarge conserved domains of low DNA methylation maintained by 5-hydroxymethycytosine and Dnmt3a
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-11-16 | E-GEOD-49191 | biostudies-arrayexpress
TranscriptomicsLarge conserved domains of low DNA methylation maintained by 5-hydroxymethycytosine and Dnmt3a [RNA-Seq]
To investigate the global transcriptome expression in Wild Type mouse hematopoietic stem cells, we performed high-throughput sequencing of Poly A+ RNA (RNA-Seq) from purified HSCs (SP-KSL-CD150+). With biological duplicates, more than 200 million reads in total were obtained. Mouse hematopoietic ste...
ORGANISM(S): Mus musculus 
2013-11-16 | E-GEOD-49715 | biostudies-arrayexpress
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