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TranscriptomicsStage-specific control of early B cell development by the transcription factor Ikaros
Ikaros is an essential regulator of lymphopoiesis. Here, we studied the B-cell-specific function of Ikaros by conditional Ikzf1 inactivation in pro-B cells. B-cell development was arrested at an aberrant ‘pro-B’ cell stage characterized by increased cell adhesion and loss of pre-B cell receptor sign...
ORGANISM(S): Mus musculus 
2014-02-09 | E-GEOD-53595 | biostudies-arrayexpress
GenomicsMolecular role of the PAX5-ETV6 oncoprotein in promoting B cell acute lymphoblastic leukemia
PAX5 is a tumor suppressor in B-ALL, while the role of PAX5 fusion proteins in B-ALL development is largely unknown. Here we studied the function of PAX5-ETV6 and PAX5- FOXP1 in mice expressing these proteins from the Pax5 locus. Both proteins arrested Blymphopoiesis at the pro-B-to-pre-B cell trans...
ORGANISM(S): Mus musculus 
2016-07-30 | E-GEOD-84987 | biostudies-arrayexpress
UnknownLimited Longitudinal Change in Self-reported Spatial Navigation Ability in Preclinical Alzheimer Disease.
Not available
S-EPMC8881346 | biostudies-literature
TranscriptomicsTranscriptomic responses to salinity stress in invasive and native blue mussels (genus Mytilus)
The invasive marine mussel Mytilus galloprovincialis has displaced the native congener Mytilus trossulus from central and southern California, but the native species remains dominant at more northerly sites that have high levels of freshwater input. To determine the extent to which interspecific dif...
ORGANISM(S): Mytilus galloprovincialis 
2011-01-10 | E-GEOD-25111 | biostudies-arrayexpress
TranscriptomicsMicroarray gene expression profiles from temperature acclimated atrial, ventricular compact and spongy tissues of Pacific bluefin tuna Thunnus orientalis
In this study, we examined the transcriptomic responses to temperature acclimation (14oC, 20oC, and 25oC) in atrial and ventricular tissues of Pacific bluefin tuna (PBFT). A global gene expression analysis using a bluefin tuna-specific microarray indicated profound changes in expression of genes ass...
ORGANISM(S): Thunnus orientalis 
2012-03-31 | E-GEOD-36886 | biostudies-arrayexpress
TranscriptomicsMicroarray gene expression profiles from mature gonad tissues of Atlantic Bluefin Tuna, Thunnus Thynnus in the Gulf of Mexico
The aim of this investigation was to compare transcription profiles from the ovaries and testes of mature T. thynnus to establish sex specific variations underlying their reproductive physiology. Two condition experiment, testis vs ovarian tissue. Biological replicates 4 male testes and 4 female ova...
ORGANISM(S): Thunnus thynnus 
2012-02-20 | E-GEOD-34084 | biostudies-arrayexpress
UnknownDynamic landscape and regulation of RNA editing in mammals.
Not available
S-EPMC5723435 | biostudies-literature
UnknownMeasurement of the differential cross section for top quark pair production in pp collisions at [Formula: see text].
Not available
S-EPMC4657759 | biostudies-literature
UnknownSearch for supersymmetry in pp collisions at [Formula: see text] TeV in events with a single lepton, jets, and missing transverse momentum.
Not available
S-EPMC4370766 | biostudies-literature
UnknownSearch for heavy neutrinos and [Formula: see text] bosons with right-handed couplings in proton-proton collisions at [Formula: see text].
Not available
S-EPMC4371073 | biostudies-literature
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