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GenomicsChIP-seq of HNF4A and GATA6 in oesophageal adenocaricnoma OE19 cells
The genome-wide binding sites of transcription factors provide insight into their regulatory function. We used chromatin immunoprecipitaition with high-throughput sequencing (ChIP-seq) to identify the genomic binding sites of HNF4A and GATA6 in OE19 cells.
ORGANISM(S): Homo sapiens 
2019-02-09 | E-MTAB-6858 | biostudies-arrayexpress
TranscriptomicsATAC-seq of oesophageal adenocarcinoma patient samples
Open chromatin profiling (ATAC-seq) of human oesophageal adenocarcinoma patient samples.
ORGANISM(S): Homo sapiens 
2020-09-30 | E-MTAB-8447 | biostudies-arrayexpress
GenomicsKLF5 ChIP-seq in CP-A and OE19 cells
To identify DNA binding sites of KLF5 in CP-A and OE19 cells, we carried out ChIP-seq.
ORGANISM(S): Homo sapiens 
2020-09-30 | E-MTAB-8568 | biostudies-arrayexpress
TranscriptomicsATAC-seq of CP-A Barrett's oesophagus cells
The open chromatin of Barrett's oesophagus cell line CP-A has been profiled by ATAC-seq.
ORGANISM(S): Homo sapiens 
2020-09-30 | E-MTAB-8994 | biostudies-arrayexpress
TranscriptomicsATAC-seq of human Barrett's oesophagus tissue
Barrett's esophagus is the assumed precusor to oesophageal adenocarcinoma. We profiled the open chromatin of human Barrett's biopsies to gain insight into its molecular basis.
ORGANISM(S): Homo sapiens 
2019-02-04 | E-MTAB-6751 | biostudies-arrayexpress
GenomicsH3K27ac ChIP-seq of Fh1-WT, Fh1-KO and Fh1-rec cells
To identify active regulatory regions of the genome, we performed H3K27ac ChIP-seq.
ORGANISM(S): Mus musculus 
2022-09-01 | E-MTAB-11790 | biostudies-arrayexpress
TranscriptomicsATAC-seq of Het1A cells with overexpression of HNF4A or GATA6
To determine the ability of HNF4A and GATA6 to drive open chromatin formation, either HNF4A or GATA6 were overexpressed in normal oesophageal Het1A cells and ATAC-seq was performed.
ORGANISM(S): Homo sapiens 
2019-02-04 | E-MTAB-6931 | biostudies-arrayexpress
TranscriptomicsATAC-seq of oesophageal adenocarcinoma cell line MFD-1
The open chromatin of new esophageal adenocarcinoma cell line MFD-1 has been profiled by ATAC-seq.
ORGANISM(S): Homo sapiens 
2018-04-06 | E-MTAB-6720 | biostudies-arrayexpress
TranscriptomicsTotal RNA-seq of human oesophageal adenocarcinoma cell line OE19 treated with siNT, siHNF4A, siGATA6 and siHNF4A+siGATA6 for 72 hours
To investigate the role of transcription factors in oesophageal adenocarcinoma, transcription factors were knocked down using siRNA and RNA was extracted and sequenced to identify target genes.
ORGANISM(S): Homo sapiens 
2019-02-04 | E-MTAB-6756 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Fh1-WT and Fh1-KO treated with either siNT or siFoxa2
To identify the transcriptional targets of Foxa2, we treated Fh1-WT or Fh1-KO cells with either siNT or siFoxa2 and subsequent RNA-sequencing.
ORGANISM(S): Mus musculus 
2022-09-01 | E-MTAB-11782 | biostudies-arrayexpress
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