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GenomicsDNA methylation changes are a late event in Acute Promyelocytic Leukemia and coincide with loss of transcription factor binding (sequencing)
The origin of aberrant DNA methylation in cancer remains largely unknown. In this study, we elucidated the DNA methylome in primary Acute Promyelocytic Leukemia (APL) and the role of PML-RARa in establishing these patterns. APL patients showed increased genome-wide DNA methylation with higher variab...
ORGANISM(S): Homo sapiens 
2012-11-08 | E-GEOD-42044 | biostudies-arrayexpress
GenomicsDirect but No Transgenerational Effects of Decitabine and Vorinostat on Male Fertility
Epigenetic drugs actively altering the epigenome of tumours have been developed for use in anti-cancer therapies. However, these drugs could potentially also affect the DNA methylome of spermatozoa that seems to be essential for male fertility. Here, we analysed possible direct and transgenerational...
ORGANISM(S): Mus musculus 
2015-03-03 | E-GEOD-59575 | biostudies-arrayexpress
GenomicsIncreased DNA Methylation of Dnmt3b-Targets Impairs Leukemogenesis (RRBS)
The de novo DNA methyltransferases Dnmt3a and Dnmt3b are of crucial importance in hematopoietic stem cells, and Dnmt3b has recently been shown to play a role in genic methylation. Forced Dnmt3b expression induced widespread DNA hypermethylation in myc-bcl2 induced leukemias, especially at promoters ...
ORGANISM(S): Mus musculus 
2016-01-11 | E-GEOD-71039 | biostudies-arrayexpress
TranscriptomicsIncreased DNA Methylation of Dnmt3b-Targets Impairs Leukemogenesis
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2016-01-11 | E-GEOD-71041 | biostudies-arrayexpress
GenomicsExamination of genome-wide methylation changes in lung cancer cell lines A549 (A) and HTB56 (H) [RRBS-Seq experiments]
Cancer cell phenotypes are partially determined by epigenetic specifications such as DNA methylation. Metastasis development is a late event in cancerogenesis and might be associated with epigenetic alterations. Here, we analyzed genome wide DNA methylation changes that were associated with pro-meta...
ORGANISM(S): Homo sapiens 
2013-12-18 | E-GEOD-52140 | biostudies-arrayexpress
GenomicsDNA Methyltransferase inhibition reverses epigenetically embedded phenotypes in lung cancer preferentially affecting Polycomb target genes
Cancer cell phenotypes are partially determined by epigenetic specifications such as DNA methylation. Metastasis development is a late event in cancerogenesis and might be associated with epigenetic alterations. Here, we analyzed genome wide DNA methylation changes that were associated with pro-meta...
ORGANISM(S): Homo sapiens 
2013-12-18 | E-GEOD-44390 | biostudies-arrayexpress
TranscriptomicsIncreased DNA Methylation of Dnmt3b-Targets Impairs Leukemogenesis (expression)
Here, we analyzed global gene expression changes that were associated with over expression of Dnmt3b in MLL-AF9 induced leukemias using the Affymetrix microarray platform. Changes in global gene expression were determined with Affymetrix microarrays in MLL-AF9 induced leukemias over expressing Dnmt3...
ORGANISM(S): Mus musculus 
2016-01-11 | E-GEOD-71040 | biostudies-arrayexpress
TranscriptomicsChanges in global gene expression in lung cancer cell lines A549 (A) and HTB56 (H) [Affymetrix microarrays]
Here, we analyzed global gene expression changes that were associated with pro-metastatic phenotypes in non-small cell lung cancer using the Affymetrix microarray platform. Changes in global gene expression were determined with Affymetrix microarrays in lung cancer cell lines A549 (A) and HTB56 (H)....
ORGANISM(S): Homo sapiens 
2013-12-18 | E-GEOD-52143 | biostudies-arrayexpress
TranscriptomicsExamination of genome-wide methylation changes in lung cancer cell lines A549 (A) and HTB56 (H) [HumanMethylation27 BeadChip experiments]
Cancer cell phenotypes are partially determined by epigenetic specifications such as DNA methylation. Metastasis development is a late event in cancerogenesis and might be associated with epigenetic alterations. Here, we analyzed genome wide DNA methylation changes that were associated with pro-meta...
ORGANISM(S): Homo sapiens 
2013-12-18 | E-GEOD-52144 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human mesenchymal stromal cells to reveal senescence associated gene expression changes
Transcription profiling of human mesenchymal cells (MSCs) after ex vivo expansion under culture conditions supporting extensive cell proliferation. Highly efficient cell expansion within short time (~40 days) and comparison of gene expression profiles from MSCs after primary seeding, defined as earl...
ORGANISM(S): Homo sapiens 
2009-12-31 | E-MEXP-1997 | biostudies-arrayexpress
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