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TranscriptomicsChanges in global gene expression profiles induced by HPV 16 E6 oncoprotein variants in cervical carcinoma C33-A cells
We analyzed the effects of the expression of HPV 16 E6 oncoprotein variants (AA-a, AA-c, E-A176/G350, E-C188/G350, E-G350), and the E- Prototype in global gene expression profiles in an in vitro model. E6 gene was cloned into an expression vector fused to GFP and was transfected in C33-A cells. A...
ORGANISM(S): Homo sapiens 
2015-11-20 | E-GEOD-73761 | biostudies-arrayexpress
TranscriptomicsGENE EXPRESSION PROFILE REGULATED BY THE HPV16-E7 ONCOPROTEIN AND ESTRADIOL IN CERVICAL TISSUE
The HPV16-E7 oncoprotein and 17β-estradiol are import factors for the induction of premalignant lesions and cervical cancer. The study of these factors is crucial for a better understanding of cervical tumorigenesis. In this study, we performed a microarray analysis to obtain a global gene expressi...
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-46890 | biostudies-arrayexpress
TranscriptomicsGenome-wide mRNA expression profiles induced by infection with the pandemic and seasonal influenza A viruses in macrophages
Infection with pandemic A/H1N1 influenza virus induces high levels of circulating and lung pro-inflammatory cytokines and chemokines in experimental models and humans. These inflammatory mediators contribute to poor clinical outcomes of this infection. To compare the regulation of inflammatory respo...
ORGANISM(S): Homo sapiens 
2012-06-09 | E-GEOD-36012 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression between skin and cervix induced by the E7 oncoprotein in a transgenic mouse model
HPV16 E7 oncoprotein expression in K14E7 transgenic mice induces cervical cancer after 6 months of treatment with the co-carcinogen 17M-NM-2-estradiol. In untreated mice, E7 also induces skin tumors late in life, albeit at low penetrance. These findings indicate that E7 alters cellular functions in ...
ORGANISM(S): Mus musculus 
2012-06-09 | E-GEOD-36219 | biostudies-arrayexpress
UnknownEffect of Direct Transportation to Thrombectomy-Capable Center vs Local Stroke Center on Neurological Outcomes in Patients With Suspected Large-Vessel Occlusion Stroke in Nonurban Areas: The RACECAT Randomized Clinical Trial.
Not available
S-EPMC9073661 | biostudies-literature
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