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TranscriptomicsA SUMOylated C-terminus fragment of glutamate transporter EAAT2 linked to inherited ALS mediates motor axon impairment
Downregulation of expression and activity levels of the astroglial glutamate transporter EAAT2 is thought to be implicated in motor neuron excitotoxicity in amyotrophic lateral sclerosis (ALS). We previously reported that EAAT2 is cleaved by caspase-3 at the cytosolic C-terminus domain, impairing th...
ORGANISM(S): Mus musculus 
2011-07-19 | E-GEOD-26070 | biostudies-arrayexpress
TranscriptomicsDevelopmental influence of the cellular prion protein on the gene expression profile in mouse hippocampus
A key event in the pathogenic process of prion diseases is the conversion of the cellular prion protein (PrPC) to an abnormal and protease-resistant isoform (PrPSc). Mice lacking PrP are resistant to prion infection, and down-regulation of PrPC during prion infection prevents neuronal loss and the p...
ORGANISM(S): Mus musculus 
2011-04-12 | E-GEOD-21718 | biostudies-arrayexpress
TranscriptomicsParkinson's disease-associated DJ-1 is required for the expression of GDNF receptor Ret in human neuroblastoma cells
DJ-1 is an atypical peroxiredoxin-like peroxidase that may act as a redox-dependent chaperone and a regulator of transcription. To explore DJ-1-mediated transcriptional control in Parkinsonâ??s disease (PD), we generated human neuroblastoma cells with inducible knock-down of DJ-1 expression. We then...
ORGANISM(S): Homo sapiens 
2010-04-28 | E-GEOD-17204 | biostudies-arrayexpress
TranscriptomicsUnexpected expression of alpha- and beta-globin in mesencephalic dopaminergic neurons and glial cells
The mesencephalic dopaminergic (mDA) cell system is composed by two major groups of projecting cells in the Substantia Nigra (A9 neurons) and the Ventral Tegmental Area (A10 cells). A9 neurons form the nigrostriatal pathway and are involved in regulating voluntary movements and postural reflexes. Th...
ORGANISM(S): Mus musculus 
2010-02-25 | E-GEOD-16192 | biostudies-arrayexpress
TranscriptomicsBlood transcriptomics of drug-naive sporadic Parkinson'?s disease patients
Parkinson's disease (PD) is a chronic progressive neurodegenerative disorder that is clinically defined in terms of motor symptoms. These are preceded by prodromal non-motor manifestations that prove the systemic nature of the disease. Identifying genes and pathways altered in living patients provid...
ORGANISM(S): Homo sapiens 
2015-10-29 | E-GEOD-72267 | biostudies-arrayexpress
UnknownUsing Gene Ontology to describe the role of the neurexin-neuroligin-SHANK complex in human, mouse and rat and its relevance to autism.
Not available
S-EPMC4458007 | biostudies-literature
TranscriptomicsGenome-wide expression profiling and functional characterization of SCA28 lymphoblastoid cell lines.
To identify altered pathways in SCA28 LCLs, we performed a whole genome expression profiling, based on Affymetrix Human Genome U133A 2.0 Chip Array, on LCLs from four unrelated patients, each carrying a different AFG3L2 mutation. Gene expression profiling of 4 patients and 6 healthy controls
ORGANISM(S): Homo sapiens 
2013-06-21 | E-GEOD-42406 | biostudies-arrayexpress
TranscriptomicsAscl1, Nurr1 and Lmx1 convert mouse and human fibroblasts into functional dopaminergic neurons without passing through an intermediate precursor state
Lineage-specific transcription factors, which drive cellular identity during embryogenesis, have been shown to convert cell fate when express ectopically in heterologous cells. Herein, we screened the key molecular factors governing the dopaminergic neuronal specification during brain development fo...
ORGANISM(S): Mus musculus 
2011-07-04 | E-GEOD-27174 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human glioblastoma cell lines after treatment with two ubiquitin-proteasome system inhibitors to characterize the molecular signals of cell death by necrosis
The regulation of necrotic death and its relevance in anti-cancer therapy are largely unknown. Here we have investigated the pro-apoptotic and pro-necrotic activities of two ubiquitin-proteasome system inhibitors (UPSIs): bortezomib and G5. The present study points out that the glioblastoma cell lin...
ORGANISM(S): Homo sapiens 
2009-10-16 | E-GEOD-14889 | biostudies-arrayexpress
TranscriptomicsDNA damage-induced differentiation of NSC
Murine ES-derived neural stem cells (NSC) were not irradiated (ctrl) or irradiated with 10Gy and cultured for 7 days (irr). The goal was to study the gene expression changes in NSC at d7 after irradiation. Total RNA was extracted from 4 ctrl and 4 irr samples (biological quadruplicates).
ORGANISM(S): Mus musculus 
2013-07-25 | E-GEOD-38031 | biostudies-arrayexpress
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