Sort   by:  
 Page size 
MetabolomicsOPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response

Ferroptosis, an iron-dependent form of nonapoptotic cell death mediated by lipid peroxidation, has been implicated in the pathogenesis of multiple diseases. Subcellular organelles play pivotal roles in the regulation of ferroptosis, but the mechanisms underlying the contributions of the mitochond...

2025-07-14 | MTBLS10544 | MetaboLights
MetabolomicsResting natural killer cell homeostasis relies on tryptophan/NAD+ metabolism and HIF-1α

Natural killer (NK) cells are forced to cope with different oxygen environments even under resting conditions. The adaptation to low oxygen is regulated by oxygen-sensitive transcription factors, the hypoxia-inducible factors (HIFs). The function of HIFs for NK cell activation and metabolic rewir...

2023-06-01 | MTBLS6863 | MetaboLights
MetabolomicsAftpo3 and Afdur3, the Aspergillus fumigatus Plasma Membrane Transporters of Polyamines, Regulate Polyamine Homeostasis and Itraconazole Susceptibility

Aspergillus fumigatus is a notorious opportunistic pathogen that causes Invasive Aspergillosis (IA) infections with high mortality in immunosuppressed individuals. Long-term antifungal drug azole abuse in clinical treatment and agriculture renders it ineffectual or drug resistant. Drug resistance...

2020-12-21 | MTBLS1739 | MetaboLights
ModelsProctor2011_ProteinHomeostasis_NormalCondition
This model is from the article: Modelling the Role of the Hsp70/Hsp90 System in the Maintenance of Protein Homeostasis Proctor CJ, Lorimer IAJ PLoS ONE2011; 6(7): e22038. doi:10.1371/journal.pone.0022038, Abstract: Neurodegeneration is a...
2024-09-02 | BIOMD0000000344 | BioModels
MetabolomicsIonic homeostasis, carbohydrate metabolism, and oxidative balance underlie wild soybean resistance to low potassium stress

The scarcity of potassium resources in farmland soils poses a major challenge to global food security. Wild soybean (Glycine soja), a valuable wild germplasm related to cultivated soybeans, is known for its high-stress resistance and adaptability. This study comprehensively compares two wild soyb...

2025-07-22 | MTBLS12462 | MetaboLights
MetabolomicsIonic homeostasis, carbohydrate metabolism, and oxidative balance underlie wild soybean resistance to low potassium stress

The scarcity of potassium resources in farmland soils poses a major challenge to global food security. Wild soybean (Glycine soja), a valuable wild germplasm related to cultivated soybeans, is known for its high-stress resistance and adaptability. This study comprehensively compares two wild soyb...

2026-04-12 | MTBLS14256 | MetaboLights
GenomicsCHTOP Regulates ROS Homeostasis to Modulate Chemoresistance in Colorectal Cancer
CHTOP Regulates ROS Homeostasis to Modulate Chemoresistance in Colorectal Cancer
PRJNA1378121 | ENA
GenomicsPROTECTION OF TELOMERES 1b safeguards the Arabidopsis genome by regulating ROS homeostasis
PROTECTION OF TELOMERES 1b safeguards the Arabidopsis genome by regulating ROS homeostasis
PRJNA1263492 | ENA
TranscriptomicsTranscriptional responses in Arabidopsis seedlings after hydrogen peroxide treatment
Excessive levels of reactive oxygen species (ROS) cause cellular stress through damage to all classes of macromolecules and result in cell death. However, ROS can also act as signaling molecules in various biological processes. In plants, ROS signaling has been documented in environmental stress per...
ORGANISM(S): Arabidopsis thaliana 
2016-06-10 | E-GEOD-80200 | biostudies-arrayexpress
ProteomicsFeS protein levels in Arabidopsis plants expressing a mutated NEET protein
Iron-sulfur (Fe-S) clusters play an essential role in plants as protein co-factors mediating diverse electron transfer reactions. Because they can react with oxygen to form reactive oxygen species (ROS) and cause cellular damage, the biogenesis of Fe-S clusters is highly regulated. A newly discovere...
ORGANISM(S): Arabidopsis Thaliana 
2021-01-24 | PXD015447 | panorama
Sort   by:  
 Page size