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ProteomicsA Proteomics Approach Identifies RREB1 as a Crucial Molecular Target of Imidazo–Pyrazole Treatment in SKMEL-28 Melanoma Cells
In a previous study, we described the biochemical properties of a newly synthesized group of imidazopyrazole compounds. In this paper, to improve our knowledge on the pharmacological properties of these chemical compounds, we carry out a differential proteomic analysis on a hu-man melanoma cell line...
ORGANISM(S): Homo sapiens (Human) 
2024-06-21 | PXD049299 | Pride
Imidazopyrazole  cell growth inhibition  differential proteomic analysis  melanoma 
ProteomicsFraisinib: a calix[4]pyrrole derivative effective in reducing NSCLC tumor in-vivo, is found to act as ligand of the Glycine-tRNA Synthase (GARS1), a new molecular target in oncology.
Adopting a multi-proteomic approach, we evaluated the possible involvement of GARS1 in the regulation of phenotypic alterations that reduced in vivo tumorigenicity of A549 cells exposed to Fraisinib over time. For this purpose, we performed a differential proteomic analysis followed by the generatio...
ORGANISM(S): Homo sapiens (Human) 
2024-01-20 | PXD037653 | Pride
Human Cancer Chemioterapy Gars1 Lung 
UnknownGenetic perturbation of IFN-α transcriptional modulators in human endothelial cells uncovers pivotal regulators of angiogenesis.
Not available
S-EPMC7734228 | biostudies-literature
UnknownA diagnostic circulating miRNA signature as orchestrator of cell invasion via TKS4/TKS5/EFHD2 modulation in human gliomas.
Not available
S-EPMC10022260 | biostudies-literature
UnknownCardiovascular care of patients with stroke and high risk of stroke: The need for interdisciplinary action: A consensus report from the European Society of Cardiology Cardiovascular Round Table.
Not available
S-EPMC7227126 | biostudies-literature
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