Rosario Spencer S

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2-Mercaptomethyl-thiazolidines use conserved aromatic-S interactions to achieve broad-range inhibition of metallo-β-lactamases.

Not available

S-EPMC8179362 | biostudies-literature

A translational regulatory mechanism mediated by hypusinated eukaryotic initiation factor 5A facilitates beta cell identity and function

As professional secretory cells, beta cells require adaptable mRNA translation to facilitate a rapid synthesis of proteins, including insulin, in response to changing metabolic cues. Specialized mRNA translation programs are essential drivers of cellular development and differentiation. However, in ...

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

2023-10-12 | MSV000093089 | MassIVE

Trehalose enhances mitochondria deficits in human NPC1 mutant fibroblasts but disrupts mouse Purkinje cell dendritic growth ex vivo.

Not available

S-EPMC10688965 | biostudies-literature

Deoxyhypusine synthase (DHPS) mutations alter the post-translational modification of eukaryotic initiation factor 5A (eIF5A) resulting in impaired human and mouse neural homeostasis

DHPS deficiency is a rare genetic disease caused by biallelic hypomorphic variants in the Deoxyhypusine synthase (DHPS) gene. The DHPS enzyme functions in mRNA translation by catalyzing the post-translational modification, and therefore activation, of the eukaryotic initiation factor 5A (eIF5A). The...

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

2023-06-06 | MSV000092112 | MassIVE

Triage and care for women with symptoms or diagnosis of pregnancy loss between 14 + 0 and 21 + 6 weeks' gestation.

Not available

S-EPMC12724057 | biostudies-literature

SAND: a comprehensive annotation of class D β-lactamases using structural alignment-based numbering.

Not available

S-EPMC12217458 | biostudies-literature

Factors associated with COVID-19 vaccine acceptance and hesitancy among residents of Northern California jails.

Not available

S-EPMC8920969 | biostudies-literature

Changing Trends in Complications and Mortality Rates Among US Youth and Young Adults With HIV Infection in the Era of Combination Antiretroviral Therapy.