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TranscriptomicsExpression of miR-200c in claudin-low breast cancer alters stem cell functionality, enhances chemosensitivity and reduces metastatic potential
Claudin-low tumors are a highly aggressive breast cancer subtype with no targeted treatments and a clinically documented resistance to chemotherapy. They are significantly enriched in cancer stem cells (CSCs), which makes claudin-low tumor models particularly attractive for studying CSC behavior and...
ORGANISM(S): Mus musculus 
2015-06-22 | E-GEOD-62230 | biostudies-arrayexpress
UnknownReplacing Computed Tomography with "Rapid" Magnetic Resonance Imaging for Ventricular Shunt Imaging.
Not available
S-EPMC8322500 | biostudies-literature
MetabolomicsFeatures of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study
Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based on reported deficit...
2024-01-12 | MTBLS850 | MetaboLights
TranscriptomicsPTEN intact and NULL prostates in intact and castrate mice.
We performed expression profiling of prostates of 3 month wild-type and PTEN NULL mice and assessed the response to 3 days of castration. Seven three month old WT and PbCre x PTEN f/f (PTEN NULL) mice were used. They are in the C57B6 background. Three mice in each group were castrated. Three days af...
ORGANISM(S): Mus musculus 
2011-05-19 | E-GEOD-24691 | biostudies-arrayexpress
TranscriptomicsComparative oncogenomics identifies breast tumors enriched in functional tumor initiating cells
The claudin-low subtype is a recently identified rare molecular subtype of human breast cancer that expresses low levels of tight and adherens junction genes and shows high expression of epithelial-to-mesenchymal transition (EMT) genes. These tumors are enriched in gene expression signatures derive...
ORGANISM(S): Mus musculus 
2011-08-14 | E-GEOD-27101 | biostudies-arrayexpress
TranscriptomicsTranscriptomic Classification of Genetically Engineered Mouse Models of Breast Carcinoma Identifies Human Subtype Counterparts
Background: Human breast cancer is a heterogeneous disease consisting of multiple molecular subtypes. Genetically engineered mouse models (GEMMs) are useful resources for studying breast cancers in vivo under genetically controlled and immune competent conditions. Identifying murine models with cons...
ORGANISM(S): Mus musculus 
2013-11-04 | E-GEOD-42640 | biostudies-arrayexpress
UnknownObesity-Linked PPARγ S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3.
Not available
S-EPMC7543662 | biostudies-literature
UnknownLong-term male-specific chronic pain via telomere- and p53‑mediated spinal cord cellular senescence.
Not available
S-EPMC9012275 | biostudies-literature
UnknownA homozygous stop-gain variant in ARHGAP42 is associated with childhood interstitial lung disease, systemic hypertension, and immunological findings.
Not available
S-EPMC8289122 | biostudies-literature
UnknownA large-scale transcriptome-wide association study (TWAS) of 10 blood cell phenotypes reveals complexities of TWAS fine-mapping.
Not available
S-EPMC8887641 | biostudies-literature
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