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Reprogramming human somatic cells into induced pluripotent stem cells (iPSC) has been suspected of causing de novo copy number variations (CNVs). To explore this issue, we performed a whole-genome and transcriptome analysis of 20 human iPSC lines derived from primary skin fibroblasts of 7 individual...
ORGANISM(S): Homo sapiens 
We report here unrelated HSE patients with autosomal recessive (AR) or autosomal dominant (AD) TRIF deficiency. The AR form of the disease is due to a homozygous nonsense mutation, resulting in a complete absence of the TRIF protein. Both the TLR3 and the TRIF-dependent TLR4 signaling pathways are a...
ORGANISM(S): Homo sapiens 
A common reference experiment design was performed. mRNAs from 149 New Zealand colorectal cancer samples were labeled with Cy5 and a common reference RNA from 12 cell lines were labeled with Cy3. Data were log2 transformed and normalized. Class prediction was performed to identify genes capable of p...
ORGANISM(S): Homo sapiens 
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