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ProteomicsComposition of Rosenthal fibers in Alexander disease patients and mouse models
Alexander disease (AxD) is a fatal neurodegenerative disorder characterized by the presence in astrocytes of protein aggregates called Rosenthal fibers (RFs). In this work, we used a new biochemical fractionation method to enrich for RFs followed by analysis of this fraction using quantitative iTRA...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2016-05-23 | PXD002448 | Pride
Alexander disease Rosenthal fibers Itraq 8-plex 
UnknownComposition of Rosenthal Fibers, the Protein Aggregate Hallmark of Alexander Disease.
Not available
S-EPMC5036859 | biostudies-literature
UnknownThe Alexander disease-causing glial fibrillary acidic protein mutant, R416W, accumulates into Rosenthal fibers by a pathway that involves filament aggregation and the association of alpha B-crystallin and HSP27.
Not available
S-EPMC1559481 | biostudies-literature
UnknownThe origin of Rosenthal fibers and their contributions to astrocyte pathology in Alexander disease.
Not available
S-EPMC5374671 | biostudies-literature
TranscriptomicsTranscription profiling of olfactory bulbs from GFAP transgenic mice and wild type mice.
Olfactory bulb transcript levels for GFAP transgenic mice compared to wildtype at 3wks and 4mos.
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-977 | biostudies-arrayexpress
TranscriptomicsGFAP transgenic mice expression analysis
Olfactory bulb transcript levels for GFAP transgenic mice compared to wildtype at 3wks and 4mos Keywords = GFAP Keywords = Rosenthal fibers Keywords = Alexander disease Keywords: other
ORGANISM(S): Mus musculus 
2005-07-20 | GSE977 | GEO
TranscriptomicsGene expression data from iPSC-derived astrocytes, comparison
Alexander disease (AxD) is a fatal neurological illness characterized by white-matter degeneration and formation of Rosenthal fibers, which contain glial fibrillary acidic protein (GFAP) as astrocytic inclusion. AxD is mainly caused by a gene mutation encoding GFAP, although the underlying pathomech...
ORGANISM(S): Homo sapiens 
2016-09-30 | GSE83374 | GEO
UnknownPhotofading in cotton fibers dyed using red, yellow, and blue direct dyes during examination with microspectrophotometry (MSP).
Not available
S-EPMC5729760 | biostudies-literature
UnknownGFAP and its role in Alexander disease.
Not available
S-EPMC2702672 | biostudies-literature
GenomicsMus musculus
GFAP transgenic mice expression analysis
PRJNA88019 | ENA
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